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dc.contributor.authorHaro, Carmenes_ES
dc.contributor.authorLanda, Blanca B.es_ES
dc.contributor.authorPérez-Jiménez, Franciscoes_ES
dc.identifier.citationJournal of Nutritional Biochemistry 27: 27-31 (2016)es_ES
dc.descriptionHaro, Carmen et al.es_ES
dc.description.abstractIntestinal microbiota changes may be involved in the development of metabolic syndrome (MetS), which is a multicomponent disorder frequently associated with obesity. The aim of this study was to test the effect of consuming two healthy diets: a Mediterranean diet and a low-fat high-carbohydrate diet, for 2 years in the gut microbiota of MetS patients and those in the control group. We analyzed the differences in the bacterial community structure between the groups after 2 years of dietary intervention (Mediterranean or low-fat diet) through quantitative polymerase chain reaction using primers, targeting specific bacterial taxa. We observed, at basal time, that the abundance of Bacteroides, Eubacterium and Lactobacillus genera is lower in the control group than in MetS patients, while Bacteroides fragilis group, Parabacteroides distasonis, Bacteroides thetaiotaomicron, Faecalibacterium prausnitzii, Fusobacterium nucleatum, Bifidobacterium longum, Bifidobacterium adolescentis, Ruminococcus flavefaciens subgroup and Eubacterium rectale are depleted in MetS patients (all P values <.05). Additionally, we found that long-term consumption of Mediterranean diet partially restores the population of P. distasonis, B. thetaiotaomicron, F. prausnitzii, B. adolescentis and B. longum in MetS patients (all P values <.05). Our results suggest that the Mediterranean diet could be a useful tool to restore potentially beneficial members of the gutes_ES
dc.description.sponsorshipThe CORDIOPREV study is supported by the Fundación Patrimonio Comunal Olivarero, Junta de Andalucía (Consejería de Salud, Consejería de Agricultura y Pesca, Consejería de Innovación and Ciencia y Empresa), Diputaciones de Jaén y Córdoba, Centro de Excelencia en Investigación sobre Aceite de Oliva y Salud and Ministerio de Medio Ambiente, Medio Rural y Marino and Gobierno de España. In addition, it was partly supported by research grants from the Ministerio de Ciencia e Innovación (AGL2009-122270 to J.L.-M., FIS PI10/01041 to P.P.-M. and PI10/02412 to F.P.-J.); Ministerio de Economia y Competitividad (AGL2012/39615 to J.L.-M.); Consejería de Economía, Innovación y Ciencia, Proyectos de Investigación de Excelencia, Junta de Andalucía (AGR922 to F.P.-J.); Consejería de Salud, Junta de Andalucía (PI0193/09 to J.L.-M., 0118/08 to F.F.-J., PI-0252/09 to J.D.-L. and PI-0058/10 to P.P.-M.); Consejería de Innovación Ciencia y Empresa (CVI-7450 to J.L.-M.); and Fondo Europeo de Desarrollo Regional. Antonio Camargo is supported by an Instituto de Salud Carlos III research contract (Programa Miguel-Servet CP14/00114). Carmen Haro is supported by an Instituto de Salud Carlos III research fellow/contract (Programa PFIS F111/00394).es_ES
dc.subjectMetabolic syndromees_ES
dc.subjectMediterranean dietes_ES
dc.subjectCardiovascular diseasees_ES
dc.titleThe gut microbial community in metabolic syndrome patients is modified by dietes_ES
dc.description.peerreviewedPeer reviewedes_ES
dc.contributor.funderFundación Patrimonio Comunal Olivareroes_ES
dc.contributor.funderJunta de Andalucíaes_ES
dc.contributor.funderDiputación de Jaénes_ES
dc.contributor.funderDiputación de Córdobaes_ES
dc.contributor.funderMinisterio de Medio Ambiente y Medio Rural y Marino (España)es_ES
dc.contributor.funderMinisterio de Ciencia e Innovación (España)es_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderEuropean Commissiones_ES
dc.contributor.funderInstituto de Salud Carlos IIIes_ES
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