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Title

The gut microbial community in metabolic syndrome patients is modified by diet

AuthorsHaro, Carmen; Landa, Blanca B. ; Pérez-Jiménez, Francisco
KeywordsMicrobiota
Obesity
Metabolic syndrome
Mediterranean diet
Cardiovascular disease
Issue DateJan-2016
PublisherElsevier
CitationJournal of Nutritional Biochemistry 27: 27-31 (2016)
AbstractIntestinal microbiota changes may be involved in the development of metabolic syndrome (MetS), which is a multicomponent disorder frequently associated with obesity. The aim of this study was to test the effect of consuming two healthy diets: a Mediterranean diet and a low-fat high-carbohydrate diet, for 2 years in the gut microbiota of MetS patients and those in the control group. We analyzed the differences in the bacterial community structure between the groups after 2 years of dietary intervention (Mediterranean or low-fat diet) through quantitative polymerase chain reaction using primers, targeting specific bacterial taxa. We observed, at basal time, that the abundance of Bacteroides, Eubacterium and Lactobacillus genera is lower in the control group than in MetS patients, while Bacteroides fragilis group, Parabacteroides distasonis, Bacteroides thetaiotaomicron, Faecalibacterium prausnitzii, Fusobacterium nucleatum, Bifidobacterium longum, Bifidobacterium adolescentis, Ruminococcus flavefaciens subgroup and Eubacterium rectale are depleted in MetS patients (all P values <.05). Additionally, we found that long-term consumption of Mediterranean diet partially restores the population of P. distasonis, B. thetaiotaomicron, F. prausnitzii, B. adolescentis and B. longum in MetS patients (all P values <.05). Our results suggest that the Mediterranean diet could be a useful tool to restore potentially beneficial members of the gut
DescriptionHaro, Carmen et al.
Publisher version (URL)http://doi.org/10.1016/j.jnutbio.2015.08.011
URIhttp://hdl.handle.net/10261/158394
DOI10.1016/j.jnutbio.2015.08.011
ISSN0955-2863
Appears in Collections:(IAS) Artículos
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