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Immunogenetic pathogenesis of celiac disease and non-celiac gluten sensitivity

AutorEscudero-Hernández, Celia; Salvador Peña, Amado; Bernardo, David
Palabras claveCeliac disease
Oral tolerance
Non-celiac gluten sensitivity
Gluten-free diet
Fecha de publicación2016
EditorSpringer Nature
CitaciónCurrent Gastroenterology Reports 18(7): 36 (2016)
ResumenCeliac disease is the most common oral intolerance in Western countries. It results from an immune response towards gluten proteins from certain cereals in genetically predisposed individuals (HLA-DQ2 and/or HLA-DQ8). Its pathogenesis involves the adaptive (HLA molecules, transglutaminase 2, dendritic cells, and CD4 T-cells) and the innate immunity with an IL-15-mediated response elicited in the intraepithelial compartment. At present, the only treatment is a permanent strict gluten-free diet (GFD). Multidisciplinary studies have provided a deeper insight of the genetic and immunological factors and their interaction with the microbiota in the pathogenesis of the disease. Similarly, a better understanding of the composition of the toxic gluten peptides has improved the ways to detect them in food and drinks and how to monitor GFD compliance via non-invasive approaches. This review, therefore, addresses the major findings obtained in the last few years including the re-discovery of non-celiac gluten sensitivity.
Identificadoresdoi: 10.1007/s11894-016-0512-2
e-issn: 1534-312X
issn: 1522-8037
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