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dc.contributor.authorSala-Vila, Aleix-
dc.contributor.authorNavarro-Lérida, Inmaculada-
dc.contributor.authorBalsinde, Jesús-
dc.contributor.authorPol, Albert-
dc.contributor.authorPozo, Miguel A. del-
dc.date.accessioned2017-11-28T10:43:31Z-
dc.date.available2017-11-28T10:43:31Z-
dc.date.issued2016-
dc.identifierdoi: 10.1038/srep27351-
dc.identifierissn: 2045-2322-
dc.identifier.citationScientific Reports 6: 27351 (2016)-
dc.identifier.urihttp://hdl.handle.net/10261/157792-
dc.descriptionThis work is licensed under a Creative Commons Attribution 4.0 International License.-- et al.-
dc.description.abstractThe mitochondria-associated membrane (MAM) is a specialized subdomain of the endoplasmic reticulum (ER) which acts as an intracellular signaling hub. MAM dysfunction has been related to liver disease. We report a high-throughput mass spectrometry-based proteomics characterization of MAMs from mouse liver, which portrays them as an extremely complex compartment involved in different metabolic processes, including steroid metabolism. Interestingly, we identified caveolin-1 (CAV1) as an integral component of hepatic MAMs, which determine the relative cholesterol content of these ER subdomains. Finally, a detailed comparative proteomics analysis between MAMs from wild type and CAV1-deficient mice suggests that functional CAV1 contributes to the recruitment and regulation of intracellular steroid and lipoprotein metabolism-related processes accrued at MAMs. The potential impact of these novel aspects of CAV1 biology on global cell homeostasis and disease is discussed.-
dc.description.sponsorshipGrant support: M.A.d.P. was supported by grants SAF2011-25047, SAF2014-51876-R, and CSD2009-0016 from Spanish Ministry of Economy and Competitiveness (MINECO), 674/C/2013 from Fundació La Marató de TV3, and AICR 15-0404 from the Worldwide Cancer Research Foundation. A.P. was supported by BFU2011-23745 and CSD2009-00016 from MINECO, and La Marató de TV3. A.S.-V., who is currently holding a Miguel Servet I contract (Instituto de Salud Carlos III, Spain), was a post-doctoral fellow at CNIC from Jan 2011 to Jan 2012 thanks to a Sara Borrell contract (Instituto de Salud Carlos III, Spain). I.N.-L. was supported by a postdoctoral fellowship from the Asociación Española Contra el Cáncer (AECC). The CNIC is supported by MINECO and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (MINECO award SEV-2015-0505).-
dc.publisherNature Publishing Group-
dc.relationMINECO/ICTI2013-2016/SEV-2015-0505-
dc.relationMINECO/ICTI2013-2016/SAF2014-51876-R-
dc.relation.isversionofPublisher's version-
dc.rightsopenAccess-
dc.titleInterplay between hepatic mitochondria-associated membranes, lipid metabolism and caveolin-1 in mice-
dc.typeartículo-
dc.identifier.doi10.1038/srep27351-
dc.relation.publisherversionhttps://doi.org/10.1038/srep27351-
dc.date.updated2017-11-28T10:43:32Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.rights.licensehttp://creativecommons.org/licenses/by/4.0-
dc.contributor.funderMinisterio de Economía y Competitividad (España)-
dc.contributor.funderFundació La Marató de TV3-
dc.contributor.funderWorldwide Cancer Research-
dc.contributor.funderInstituto de Salud Carlos III-
dc.contributor.funderAmerican Institute for Cancer Research-
dc.contributor.funderCentro Nacional de Investigaciones Cardiovasculares (España)-
dc.contributor.funderAsociación Española Contra el Cáncer-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100007287es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004587es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100000969es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100005884es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100008666es_ES
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