English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/157041
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Introduction to special issue on mitochondrial redox signaling in health and disease

AuthorsBolaños, Juan P. ; Cadenas, Enrique; Duchen, Michael R.; Hampton, Mark B.; Mann, Giovanni E.; Murphy, Michael P.
Issue Date2016
CitationFree Radical Biology and Medicine 100: 1-4 (2016)
AbstractMitochondria are functional entities that harbor the energy-conservation machinery that supports cell function through the coordination of mitochondrion-derived molecules involved in the regulation of cell signaling and transcription. Conversely, mitochondria are targets of an ever-increasing number of signaling pathways and their activity is also modulated by several transcription factors. The cell's energy-redox homeostasis is primarily a function of mitochondrial oxidative phosphorylation and the formation of O2.–/H2O2. Notably, other mitochondrion-driven processes contribute to cellular homeostasis, such as mitochondrial biogenesis and dynamics, mitochondrial quality control (autophagy and mitophagy), mitochondrial proteostasis and the role of the mitochondrial unfolded protein response (UPRmt), and redox signaling in the homeostatic control of mitochondrial function. This Free Radical Biology & Medicine special issue on Mitochondrial Redox Signaling in Health and Disease covers some aspects of the myriad of processes embraced by mitochondrial biology and physiology, provides mechanistic insights linking mitochondrial function with cell function, and recognizes mitochondrial function as an amenable therapeutic target.
Publisher version (URL)https://doi.org/10.1016/j.freeradbiomed.2016.08.004
Identifiersdoi: 10.1016/j.freeradbiomed.2016.08.004
issn: 0891-5849
e-issn: 1873-4596
Appears in Collections:(IBFG) Artículos
Files in This Item:
File Description SizeFormat 
intoducionredoxsignaling.pdf268,78 kBAdobe PDFThumbnail
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.