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Título: | Bioenergetics and redox adaptations of astrocytes to neuronal activity |
Autor: | Bolaños, Juan P. CSIC ORCID | Palabras clave: | AMPK Cdh1 Glycolysis GSH Nrf2 PFKFB3 |
Fecha de publicación: | 2016 | Editor: | John Wiley & Sons International Society for Neurochemistry |
Citación: | Journal of Neurochemistry 139(S2): 115-125 (2016) | Resumen: | Neuronal activity is a high-energy demanding process recruiting all neural cells that adapt their metabolism to sustain the energy and redox balance of neurons. During neurotransmission, synaptic cleft glutamate activates its receptors in neurons and in astrocytes, before being taken up by astrocytes through energy costly transporters. In astrocytes, the energy requirement for glutamate influx is likely to be met by glycolysis. To enable this, astrocytes are constitutively glycolytic, robustly expressing 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3), an enzyme that is negligibly present in neurons by continuous degradation because of the ubiquitin-proteasome pathway via anaphase-promoting complex/cyclosome (APC)-Cdh1. Additional factors contributing to the glycolytic frame of astrocytes may include 5′-AMP-activated protein kinase (AMPK), hypoxia-inducible factor-1 (HIF-1), pyruvate kinase muscle isoform-2 (PKM2), pyruvate dehydrogenase kinase-4 (PDK4), lactate dehydrogenase-B, or monocarboxylate transporter-4 (MCT4). Neurotransmission-associated messengers, such as nitric oxide or ammonium, stimulate lactate release from astrocytes. Astrocyte-derived glycolytic lactate thus sustains the energy needs of neurons, which in contrast to astrocytes mainly rely on oxidative phosphorylation. Neuronal activity unavoidably triggers reactive oxygen species, but the antioxidant defense of neurons is weak; hence, they use glucose for oxidation through the pentose-phosphate pathway to preserve the redox status. Furthermore, neural activity is coupled with erythroid-derived erythroid-derived 2-like 2 (Nrf2) mediated transcriptional activation of antioxidant genes in astrocytes, which boost the de novo glutathione biosynthesis in neighbor neurons. Thus, the bioenergetics and redox programs of astrocytes are adapted to sustain neuronal activity and survival. Developing therapeutic strategies to interfere with these pathways may be useful to combat neurological diseases. | Versión del editor: | https://doi.org/10.1111/jnc.13486 | URI: | http://hdl.handle.net/10261/156921 | DOI: | 10.1111/jnc.13486 | Identificadores: | doi: 10.1111/jnc.13486 e-issn: 1471-4159 issn: 0022-3042 |
Aparece en las colecciones: | (IBFG) Artículos |
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redoxastrocytes.pdf | 394,12 kB | Adobe PDF | Visualizar/Abrir |
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