Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/15653
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | A new, mild, and efficient synthesis of 2,2-difluoro-3-hydroxyacids through a selective haloform reaction |
Autor: | Jiménez, Óscar; Bosch, María Pilar CSIC; Guerrero, Ángel CSIC ORCID | Palabras clave: | Fluoroorganic chemistry Selective Haloform Reaction Fluorine source |
Fecha de publicación: | 16-nov-2005 | Editor: | American Chemical Society | Citación: | Journal of Organic Chemistry 70(26): 10883–10885 (2005) | Resumen: | Long-chain 2,2-difluoro-3-hydroxyacids have been synthesized in a new, straightforward manner by treatment of 4-hydroxy-1,1,1,3,3-pentafluoroalkyl ketones, easily obtained by reaction of pentafluoroenolate 2 with aldehydes and ketones, with base under mild conditions. The reaction sequence is marked by the selective cleavage of the CO−CF3 bond, as well as the absence of products arising from the alternative CO−CF2R bond cleavage. The process represents a convenient approach for the synthesis of 2,2-difluoro-3-hydroxyacids, as it is short, provides good to excellent yields under mild conditions, and uses hexafluoro-2-propanol, a very cheap reagent, as the fluorine source. | Descripción: | 3 pages, 2 schemes, 1 chart, 1 table.-- PMID: 16356015 [PubMed].-- Printed version published Dec 23, 2005.-- Supporting information available at: http://pubs.acs.org/doi/suppl/10.1021/jo0518856 | Versión del editor: | http://dx.doi.org/10.1021/jo0518856 | URI: | http://hdl.handle.net/10261/15653 | DOI: | 10.1021/jo0518856 | ISSN: | 0022-3263 | E-ISSN: | 1520-6904 |
Aparece en las colecciones: | (IQAC) Artículos |
Mostrar el registro completo
CORE Recommender
SCOPUSTM
Citations
13
checked on 12-abr-2024
WEB OF SCIENCETM
Citations
13
checked on 26-feb-2024
Page view(s)
324
checked on 17-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.