Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/15537
Share/Export:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Title

Gold nanoparticles for selective and remote heating of β-amyloid protein aggregates

AuthorsBastús, Neus G. CSIC ORCID; Kogan, Marcelo J.; Amigo, Roger; Grillo-Bosch, Dolors; Araya, Eyleen; Turiel, Antonio CSIC ORCID ; Labarta, Amílcar; Giralt, Ernest; Puntes, Víctor F. CSIC ORCID
KeywordsGold nanoparticles
Protein aggregates
Microwaves
Molecular surgery
Issue DateSep-2007
PublisherElsevier
CitationMaterials Science and Engineering C 27(5-8): 1236-1240 (2007)
AbstractNanoparticles can be made to respond resonantly to a time-varying electromagnetic field with advantageous results related to the transfer of energy from the exciting field to the nanoparticles. The surface of each particle can be heated up, this heat being transmitted into the immediately surrounding tissue. This enables their use as hyperthermia agents delivering toxic amounts of thermal energy to targeted bodies such as tumours. Heating of nanoparticles in a magnetic field is mainly due to inductive coupling (via eddy currents), and in the case of magnetic particles, loss processes during the reorientation of the magnetization (hysteresis losses) or frictional losses (relaxational losses) if the particle can rotate in an environment of sufficiently low viscosity. We use this method to apply heat locally and remotely, dissolving toxic protein deposits of Aβ1–42 (amyloid deposits) via the combined use of weak microwave fields and gold nanoparticles (AuNP) without any bulk heating. This method can be extended to a number of systems where it may be desirable to remove proteins and other aggregates involved in different pathologies
Description5 pages, 3 figures, 2 tables.-- Issue title: "EMRS 2006 Symposium A: Current Trends in Nanoscience - from Materials to Applications" (Nice, France, May 29-Jun 2, 2006)
Publisher version (URL)https://doi.org/10.1016/j.msec.2006.08.003
URIhttp://hdl.handle.net/10261/15537
DOI10.1016/j.msec.2006.08.003
ISSN0928-4931
Appears in Collections:(ICM) Artículos
(CIN2) Artículos

Show full item record
Review this work

SCOPUSTM   
Citations

45
checked on May 24, 2022

WEB OF SCIENCETM
Citations

43
checked on May 20, 2022

Page view(s)

400
checked on May 25, 2022

Google ScholarTM

Check

Altmetric

Dimensions


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.