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http://hdl.handle.net/10261/155092
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dc.contributor.author | Martín-Ortiz, Andrea | - |
dc.contributor.author | Barile, Daniela | - |
dc.contributor.author | Salcedo, J. | - |
dc.contributor.author | Moreno, F. Javier | - |
dc.contributor.author | Clemente, Alfonso | - |
dc.contributor.author | Ruiz-Matute, Ana I. | - |
dc.contributor.author | Sanz, M. Luz | - |
dc.date.accessioned | 2017-09-14T07:51:03Z | - |
dc.date.available | 2017-09-14T07:51:03Z | - |
dc.date.issued | 2017 | - |
dc.identifier | doi: 10.1021/acs.jafc.6b05104 | - |
dc.identifier | e-issn: 1520-5118 | - |
dc.identifier | issn: 0021-8561 | - |
dc.identifier.citation | Journal of Agricultural and Food Chemistry 65(17): 3523-3531 (2017) | - |
dc.identifier.uri | http://hdl.handle.net/10261/155092 | - |
dc.description | PMCID: PMC5557284. | - |
dc.description.abstract | Changes of the abundance of caprine milk oligosaccharides (CMO) at different lactation stages have been evaluated by hydrophilic interaction liquid chromatography coupled to mass spectrometry (HILIC-Q MS) and nanoflow liquid chromatography-quadrupole-time-of-flight mass spectrometry (nano-LC-Chip-QTOF MS). Eight major oligosaccharides (OS) were quantified at different lactation stages by HILIC-Q MS, while the use of nano-LC-Chip-QToF MS allowed expanding the study to forty-nine different OS by monitoring neutral non- and fucosylated species, as well as acidic species containing not only N-acetyl-neuraminic acid or N-glycolyl-neuraminic acid residues but also the combination of both sialic acids. Overall, the most abundant OS decreased with lactation time, whereas different trends were observed for minor OS. 6′-Sialyl-lactose was the most abundant acidic OS while galactosyl-lactose isomers were identified as the most abundant neutral OS. This is the first time that a comprehensive study regarding the changes of the abundance of CMO, both neutral and acidic, at different lactation stages is carried out. | - |
dc.description.sponsorship | This work has been funded by Junta de Andalucía (project AGR2011-7626), Ministerio de Economía, Industria y Competitividad (AGL2016-80475-R, AEI/FEDER, UE), Comunidad Autónoma de Madrid (Spain), European funding from FEDER program (AVANSECAL-CM S2013/ABI-3028,) and Fundación Ramón Areces. This work was also supported by the National Institutes of Health awards R21AT006180, R01AT007079, and R01 AT008759. | - |
dc.publisher | American Chemical Society | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2016-80475-R | - |
dc.relation | S2013/ABI-3028/AVANSECAL-CM | - |
dc.relation.isversionof | Postprint | - |
dc.rights | openAccess | en_EN |
dc.subject | Lactation stages | - |
dc.subject | Hydrophilic interaction liquid chromatography | - |
dc.subject | Nanoflow liquid chromatography–quadrupole-time-of-flight mass spectrometry | - |
dc.subject | Goat milk oligosaccharides | - |
dc.title | Changes in caprine milk oligosaccharides at different lactation stages analyzed by high performance liquid chromatography coupled to mass spectrometry | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1021/acs.jafc.6b05104 | - |
dc.relation.publisherversion | https://doi.org/10.1021/acs.jafc.6b05104 | - |
dc.embargo.terms | 2018-04-10 | - |
dc.date.updated | 2017-09-14T07:51:03Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.contributor.funder | Junta de Andalucía | - |
dc.contributor.funder | Ministerio de Economía, Industria y Competitividad (España) | - |
dc.contributor.funder | National Institutes of Health (US) | - |
dc.contributor.funder | European Commission | - |
dc.contributor.funder | Comunidad de Madrid | - |
dc.contributor.funder | Fundación Ramón Areces | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/100008054 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100000002 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100012818 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100010198 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011011 | es_ES |
dc.identifier.pmid | 28393524 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.openairetype | artículo | - |
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CaprineMilkOligo.pdf | 454,36 kB | Adobe PDF | Visualizar/Abrir |
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