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Title

Laponite as carrier for controlled in vitro delivery of dexamethasone in vitreous humor models

AuthorsFraile, José M. ; Garcia-Martin, Elena; Gil, Cristina; Mayoral, José A. ; Pablo, Luis E.; Polo-Llorens, Vicente; Prieto, Esther; Vispe, Eugenio
KeywordsVitreous humor
Dexamethasone
Laponite
Controlled delivery
Corticosteroids
Issue Date2016
PublisherElsevier
CitationEuropean Journal of Pharmaceutics and Biopharmaceutics 108: 83-90 (2016)
AbstractLaponite clay is able to retain dexamethasone by simple physisorption, presumably accomplished by hydrogen bonding formation and/or complexation with sodium counterions, as shown by solid state NMR. The physisorption can be somehow modulated by changing the solvent in the adsorption process. This simple system is able to deliver dexamethasone in a controlled manner to solutions used as models for vitreous humor. The proven biocompatibility of laponite as well as its transparency in the gel state, together with the simplicity of the preparation method, makes this system suitable for future in vivo tests of ophthalmic treatment.
Publisher version (URL)https://doi.org/10.1016/j.ejpb.2016.08.015
URIhttp://hdl.handle.net/10261/154898
DOI10.1016/j.ejpb.2016.08.015
Identifiersdoi: 10.1016/j.ejpb.2016.08.015
e-issn: 1873-3441
issn: 0939-6411
Appears in Collections:(ISQCH) Artículos
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