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| Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.contributor.author | Schmidt, Harald H.H.W. | - |
| dc.contributor.author | Daiber, Andreas | - |
| dc.contributor.author | Cuadrado, Antonio | - |
| dc.date.accessioned | 2017-08-23T07:35:07Z | - |
| dc.date.available | 2017-08-23T07:35:07Z | - |
| dc.date.issued | 2015 | - |
| dc.identifier | doi: 10.1089/ars.2015.6393 | - |
| dc.identifier | e-issn: 1557-7716 | - |
| dc.identifier | issn: 1523-0864 | - |
| dc.identifier.citation | Antioxidants 23(14): 1130-1143 (2015) | - |
| dc.identifier.uri | http://hdl.handle.net/10261/154307 | - |
| dc.description | This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License.-- et al. | - |
| dc.description.abstract | [Significance]: It is generally accepted that reactive oxygen species (ROS) scavenging molecules or antioxidants exert health-promoting effects and thus their consumption as food additives and nutraceuticals has been greatly encouraged. Antioxidants may be beneficial in situations of subclinical deficiency and increased demand or acutely upon high-dose infusion. However, to date, there is little clinical evidence for the long-term benefit of most antioxidants. Alarmingly, recent evidence points even to health risks, in particular for supplements of lipophilic antioxidants. [Recent Advances]: The biological impact of ROS depends not only on their quantities but also on their chemical nature, (sub)cellular and tissue location, and the rates of their formation and degradation. Moreover, ROS serve important physiological functions; thus, inappropriate removal of ROS may cause paradoxical reductive stress and thereby induce or promote disease. [Critical Issues]: Any recommendation on antioxidants must be based on solid clinical evidence and patient-relevant outcomes rather than surrogate parameters. [Future Directions]: Such evidence-based use may include site-directed application, time-limited high dosing, (functional) pharmacological repair of oxidized biomolecules, and triggers of endogenous antioxidant response systems. Ideally, these approaches need guidance by patient stratification through predictive biomarkers and possibly imaging modalities. | - |
| dc.description.sponsorship | A.C. is the recipient of a research grant, SAF2013-43271-R, from the Spanish Ministry of Economy and Competitiveness. A.D. was supported by grants by the Federal Ministry of Education and Research to the Center of Thrombosis and Hemostasis Mainz (BMBF 01EO1003). R.S. is the recipient of a Senior Principal Research Fellowship of the National Health and Medical Research Council of Australia. Several authors of this review were supported by the European Cooperation in Science and Technology (COST Action BM1203/EU-ROS). | - |
| dc.publisher | Mary Ann Liebert | - |
| dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2013-43271-R | - |
| dc.relation.isversionof | Publisher's version | - |
| dc.rights | openAccess | - |
| dc.title | Antioxidants in translational medicine | - |
| dc.type | artículo | - |
| dc.identifier.doi | 10.1089/ars.2015.6393 | - |
| dc.relation.publisherversion | https://doi.org/10.1089/ars.2015.6393 | - |
| dc.date.updated | 2017-08-23T07:35:07Z | - |
| dc.description.version | Peer Reviewed | - |
| dc.language.rfc3066 | eng | - |
| dc.rights.license | http://creativecommons.org/licenses/by-nc/4.0/ | - |
| dc.contributor.funder | National Health and Medical Research Council (Australia) | - |
| dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
| dc.contributor.funder | European Commission | - |
| dc.relation.csic | Sí | - |
| dc.identifier.funder | http://dx.doi.org/10.13039/501100000925 | es_ES |
| dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
| dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
| dc.identifier.pmid | 26154592 | - |
| dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
| item.openairetype | artículo | - |
| item.grantfulltext | open | - |
| item.cerifentitytype | Publications | - |
| item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
| item.fulltext | With Fulltext | - |
| Aparece en las colecciones: | (IIBM) Artículos | |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| AntioxidanTranslationalMedicine.pdf | 663,32 kB | Adobe PDF |  Visualizar/Abrir |
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