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http://hdl.handle.net/10261/154166
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dc.contributor.author | Motiño, Omar | - |
dc.contributor.author | Agra, Noelia | - |
dc.contributor.author | Brea, Rocío | - |
dc.contributor.author | Domínguez-Moreno, Marina | - |
dc.contributor.author | García-Monzón, Carmelo | - |
dc.contributor.author | Carnovale, Cristina E. | - |
dc.contributor.author | Boscá, Lisardo | - |
dc.contributor.author | Casado, Marta | - |
dc.contributor.author | Mayoral, Rafael | - |
dc.contributor.author | Valdecantos, M. P. | - |
dc.contributor.author | Valverde, Ángela M. | - |
dc.contributor.author | Francés, Daniel E. | - |
dc.contributor.author | Martín-Sanz, Paloma | - |
dc.date.accessioned | 2017-08-17T12:20:25Z | - |
dc.date.available | 2017-08-17T12:20:25Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Liver Biology - Fundamental Mechanisms and Translational Applications (2016) | - |
dc.identifier.uri | http://hdl.handle.net/10261/154166 | - |
dc.description | Resumen del póster presentado a la Conferencia Liver Biology - Fundamental Mechanisms and Translational Applications, celebrada en Palm Beach (USA) del 26 de junio al 1 de julio de 2016. | - |
dc.description.abstract | Cyclooxygenase-2 (COX-2) is involved in different liver diseases but little is known about the significance of COX-2 in the development and progression of non-alcoholic steatohepatitis (NASH). This study was designed to elucidate the role of COX-2 expression in hepatocytes in the pathogenesis of steatohepatitis and hepatic fibrosis. In the present work, hepatocyte-specific COX-2 transgenic mice (hCOX-2-Tg) and their wild-type (Wt) littermates were either fed methionine-and-choline deficient (MCD) diet to establish an experimental non-alcoholic steatohepatitis (NASH) model or injected with carbon tetrachloride (CC14) to induce liver fibrosis. In our animal model, hCOX-2-Tg mice fed MCD diet showed lower grades of steatosis, ballooning and inflammation than Wt mice, in part by reduced recruitment and infiltration of hepatic macrophages, with a corresponding decrease in serum levels of pro-inflammatory cytokines. Furthermore, hCOX-2-Tg mi ce showed a significant attenuation of the MCD diet-induced increase in oxidative stress and hepatic apoptosis observed in Wt mice. Even more, hCOX-2-Tg mi ce treated with CC14 had significantly lower stages of fibrosis and less hepatic content of collagen, hydroxyproline and pro-fibrogenic markers than Wt controls. Collectively, our data indicates that constitutive hepatocyte COX-2 expression ameliorates NASH and liver fibrosis development in mice by reducing inflammation, oxidative stress and apoptosis and by modulating activation of hepatic stellate cells, respectively, suggesting a possible protective role for COX-2 induction in NASH/NAFLD progression. | - |
dc.rights | closedAccess | - |
dc.title | Cyclooxygenase-2 expression in hepatocytes attenuates non-alcoholic steatohepatitis and liver fibrosis in mice | - |
dc.type | póster de congreso | - |
dc.date.updated | 2017-08-17T12:20:25Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.relation.csic | Sí | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6670 | es_ES |
item.openairetype | póster de congreso | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
Aparece en las colecciones: | (IIBM) Comunicaciones congresos (IBV) Comunicaciones congresos |
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