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Emergence of the human DNA Damage Response Network

AuthorsArcas, Aída; Fernández-Capetillo, Óscar; Cases, Ildefonso; Rojas, A. M.
Issue DateSep-2014
CitationXII Symposium on Bioinformatics (2014)
AbstractThe DNA Damage response is a crucial signaling network that preserves the integrity of the genome. To understand how these elements have been assembled together in humans, we performed comparative genomic analyses in selected species to trace back their emergence using systematic phylogenetic analyses and estimated gene ages. The emergence of the contribution of post-translational modifications to the complex regulation of DDR was also investigated. This is the first time a systematic analysis has focused on the evolution of DDR sub-networks as a whole. Our results indicate that a DDR core, mostly constructed around metabolic activities, appeared soon after the emergence of eukaryotes, and that additional regulatory capacities appeared later through complex evolutionary process. Potential key post-translational modifications were also in place then, with interacting pairs preferentially appearing at the same evolutionary time, although modifications often led to the subsequent acquisition of new targets afterwards. We also found extensive gene loss in essential modules of the regulatory network in fungi, plants and arthropods, important for their validation as model organisms for DDR studies.
DescriptionTrabajo presentado en el XII Symposium on Bioinformatics (XII Jornadas de Bioinformática), celebrado en Sevilla del 21 al 24 de septiembre de 2014.
Appears in Collections:(IBIS) Comunicaciones congresos
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