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dc.contributor.authorRojas, A. M.es_ES
dc.contributor.authorValencia, Alfonsoes_ES
dc.date.accessioned2017-08-03T07:05:45Z-
dc.date.available2017-08-03T07:05:45Z-
dc.date.issued2014-
dc.identifier.citationRas Superfamily Small G Proteins: Biology and Mechanisms 1: 3-24 (2014)es_ES
dc.identifier.isbn978-3-7091-1806-1-
dc.identifier.urihttp://hdl.handle.net/10261/153806-
dc.descriptionWittinghofer A. (eds).es_ES
dc.description.abstractThe Ras superfamily of small GTPases illustrates a large functional diversification in the context of a preserved structural framework and a prototypic GTP-binding site. The Ras superfamily of small GTP-binding proteins is essential to regulate the cellular organization and signaling in cells. Members of this superfamily contain a structurally and mechanistically preserved GTP-binding core, with considerable functional and sequence divergence. In this chapter we review the evolutionary structure of the superfamily at the organism and sequence level, presenting a representative tree that reflects the history of the Ras superfamily including crucial evolutionary time points and detailed trees for the Rho, Ras, Rab, Arf, and Ran families. Based on this information we discuss some of the complex relationships between the evolution of proteins and the acquisition of distinctive cellular functions.es_ES
dc.language.isoenges_ES
dc.publisherSpringeres_ES
dc.rightsclosedAccesses_ES
dc.subjectRas phylogenyes_ES
dc.subjectSmall GTPaseses_ES
dc.subjectGTP-bindinges_ES
dc.subjectMultiple sequence alignmentses_ES
dc.titleEvolution of the Ras Superfamily of GTPaseses_ES
dc.typeCapítulo de libroes_ES
dc.identifier.doi10.1007/978-3-7091-1806-1_1-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1007/978-3-7091-1806-1_1es_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
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