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Título

Gas1 Is Related to the Glial Cell-derived Neurotrophic Factor Family Receptors α and Regulates Ret Signaling

AutorCabrera, Jorge Rubén ; Sánchez-Pulido, Luis; Rojas, A. M. ; Valencia, Alfonso; Mañes, Santos; Naranjo, José Ramón; Mellström, Britt
Fecha de publicación19-may-2006
EditorAmerican Society for Biochemistry and Molecular Biology
CitaciónJournal of Biological Chemistry 281(20): 14330-14339 (2006)
ResumenThe growth arrest-specific gene 1 (Gas1) protein has been proposed to function during development as an inhibitor of growth and a mediator of cell death and is also re-expressed in adult neurons during excitotoxic insult. Here we have demonstrated that the Gas1 protein shows high structural similarity to the glial cell-derived neurotrophic factor (GDNF) family receptors α, which mediate GDNF responses through the receptor tyrosine kinase Ret. We found that Gas1 binds Ret in a ligand-independent manner and sequesters Ret in lipid rafts. Signaling downstream of Ret is thus modified through a mechanism that involves the adaptor protein Shc as well as ERK, eventually blocking Akt activation. Consequently, when Gas1 is induced, Ret-mediated GDNF-dependent survival effects are compromised.
Versión del editorhttp://doi.org/10.1074/jbc.M509572200
URIhttp://hdl.handle.net/10261/153703
DOI10.1074/jbc.M509572200
ISSN0021-9258
E-ISSN1083-351X
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