English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/153675
logo share SHARE   Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


A second look at the chimpanzee genome

AuthorsKuderna, Lukas F. K.; Marqués-Bonet, Tomàs
Issue DateJul-2016
CitationAnnual Meeting of the Society for Molecular Biology and Evolution (2016)
AbstractThe initial sequencing of the chimpanzee genome and its comparison to our own constituted a major leap in the understanding of the evolutionary trajectories of our species. Nevertheless, the proper characterization of some complex regions are far from complete as even the most current iteration of the chimpanzee assembly (Pantro_2.1.4) is still a draft a decade after its initial release. In this work, we will present a complete de-novo assembly for the common Chimpanzee, incorporating several different novel technologies such as Illumina 2x250 bp overlapping paired end reads, PacBio single molecule sequencing long reads, Illumina Moleculo and Dovetail HiC-chromosomal contact maps for scaffolding. We produce a high quality assembly derived from a single male individual (Clint), boosting contiguity by over 300% on the scaffold level, and by over 750% on the contig level, additionally resolving around 230Mbps of the genome. We are able to characterize more complexity in this version of the chimpanzee genome and explore the genome wide diversity of tandem repeats and copy number variation at population level.
DescriptionTrabajo presentado en la Annual Meeting of the Society for Molecular Biology and Evolution (SMBE 2016), celebrada en Gold Coast (Queensland, Australia) del 3 al 7 de julio de 2016.
Appears in Collections:(IBE) Comunicaciones congresos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.