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Title

Melatonin as a versatile molecule to design novel multitarget hybrids against neurodegeneration

AuthorsRamos, E. ; Egea, Javier; Rios, C. de los; Marco-Contelles, José ; Romero, A.
KeywordsMelatonin
Hybrid compounds
MTDLs
Multitarget-directed ligands
Neurodegeneration
Alzheimer's disease
Antioxidant therapy
Issue Date2017
PublisherFuture Science
CitationFuture Medicinal Chemistry 9: 765- 780 (2017)
AbstractMelatonin is an indoleamine produced mainly in the pineal gland. The natural decline of melatonin levels with aging strongly contributes to the development of neurodegenerative disorders. Pleiotropic actions displayed by melatonin prevent several processes involved in neurodegeneration such as neuroinflammation, oxidative stress, excitotoxicity and/or apoptosis. This review focuses on a number of melatonin hybrids resulting from the juxtaposition of tacrine, berberine, tamoxifen, curcumin, N,N-dibenzyl(N-methyl)amine, among others, with potential therapeutic effects for the treatment of neurodegenerative diseases.
Publisher version (URL)http://dx.doi.org/10.4155/fmc-2017-0014
URIhttp://hdl.handle.net/10261/153626
DOI10.4155/fmc-2017-0014
Identifiersdoi: 10.4155/fmc-2017-0014
issn: 1756-8919
e-issn: 1756-8927
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(IQOG) Artículos
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