English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/153498
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


A non-canonical mismatch repair pathway in prokaryotes

AutorCastañeda-García, Alfredo; Prieto, A. I.; Rodríguez Beltrán, Jerónimo; Alonso, N.; Costas, Coloma; Rojas, A. M. ; Blázquez Gómez, Jesús
Fecha de publicación27-ene-2017
EditorNature Publishing Group
CitaciónNature Communications 8: 14246 (2017)
ResumenMismatch repair (MMR) is a near ubiquitous pathway, essential for the maintenance of genome stability. Members of the MutS and MutL protein families perform key steps in mismatch correction. Despite the major importance of this repair pathway, MutS–MutL are absent in almost all Actinobacteria and many Archaea. However, these organisms exhibit rates and spectra of spontaneous mutations similar to MMR-bearing species, suggesting the existence of an alternative to the canonical MutS–MutL-based MMR. Here we report that Mycobacterium smegmatis NucS/EndoMS, a putative endonuclease with no structural homology to known MMR factors, is required for mutation avoidance and anti-recombination, hallmarks of the canonical MMR. Furthermore, phenotypic analysis of naturally occurring polymorphic NucS in a M. smegmatis surrogate model, suggests the existence of M. tuberculosis mutator strains. The phylogenetic analysis of NucS indicates a complex evolutionary process leading to a disperse distribution pattern in prokaryotes. Together, these findings indicate that distinct pathways for MMR have evolved at least twice in nature.
DescripciónCastañeda-García, Alfredo et al.
Versión del editorhttp://doi.org/10.1038/ncomms14246
Aparece en las colecciones: (CNB) Artículos
(IBIS) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
ncomms14246.pdf1,46 MBAdobe PDFVista previa
Mostrar el registro completo

Artículos relacionados:

NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.