Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/153345
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | The Notch pathway regulates both the proliferation and differentiation of follicular cells in the panoistic ovary of Blattella germanica |
Autor: | Irles, Paula CSIC ORCID; Elshaer, Nashwa; Piulachs, Maria-Dolors CSIC ORCID | Palabras clave: | Notch Panoistic ovary RNAi Oogenesis Cell proliferation Drosophila |
Fecha de publicación: | ene-2016 | Editor: | Royal Society (Great Britain) | Citación: | Open Biology 6: 150197 (2017) | Resumen: | The Notch pathway is an essential regulator of cell proliferation and differentiation during development. Its involvement in insect oogenesis has been examined in insect species with meroistic ovaries, and it is known to play a fundamental role in cell fate decisions and the induction of the mitosis-to-endocycle switch in follicular cells (FCs). This work reports the functions of the main components of the Notch pathway (Notch and its ligands Delta and Serrate) during oogenesis in Blattella germanica, a phylogenetically basal species with panoistic ovary. As is revealed by RNAi-based analyses, Notch and Delta were found to contribute towards maintaining the FCs in an immature, non-apoptotic state. This ancestral function of Notch appears in opposition to the induction of transition from mitosis to endocycle that Notch exerts in Drosophila melanogaster, a change in the Notch function that might be in agreement with the evolution of the insect ovary types. Notch was also shown to play an active role in inducing ovarian follicle elongation via the regulation of the cytoskeleton. In addition, Delta and Notch interactions were seen to determine the differentiation of the posterior population of FCs. Serrate levels were found to be Notch-dependent and are involved in the control of the FC programme, although they would appear to play no crucial role in panoistic ovary oogenesis. | Versión del editor: | http://doi.org/10.1098/rsob.150197 | URI: | http://hdl.handle.net/10261/153345 | DOI: | 10.1098/rsob.150197 | ISSN: | 2046-2441 |
Aparece en las colecciones: | (IBE) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
150197.full.pdf | 2,4 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
6
checked on 31-mar-2024
SCOPUSTM
Citations
19
checked on 16-abr-2024
WEB OF SCIENCETM
Citations
17
checked on 27-feb-2024
Page view(s)
283
checked on 22-abr-2024
Download(s)
179
checked on 22-abr-2024