English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/153077
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Electrical Stimulation of Afferent Pathways for the Suppression of Pathological Tremor

AuthorsDideriksen, Jakob L.; Laine, Christopher M.; Dosen, S.; Muceli, S.; Rocón, Eduardo ; Pons Rovira, José Luis ; Benito-León, Julián; Farina, Dario
Issue Date4-Apr-2017
PublisherFrontiers Media
CitationFrontiers in Neuroscience 11: 178 (2017)
AbstractPathological tremors are involuntary oscillatory movements which cannot be fully attenuated using conventional treatments. For this reason, several studies have investigated the use of neuromuscular electrical stimulation for tremor suppression. In a recent study, however, we found that electrical stimulation below the motor threshold also suppressed tremor, indicating involvement of afferent pathways. In this study, we further explored this possibility by systematically investigating how tremor suppression by afferent stimulation depends on the stimulation settings. In this way, we aimed at identifying the optimal stimulation strategy, as well as to elucidate the underlying physiological mechanisms of tremor suppression. Stimulation strategies varying the stimulation intensity and pulse timing were tested in nine tremor patients using either intramuscular or surface stimulation. Significant tremor suppression was observed in six patients (tremor suppression > 75% was observed in three patients) and the average optimal suppression level observed across all subjects was 52%. The efficiency for each stimulation setting, however, varied substantially across patients and it was not possible to identify a single set of stimulation parameters that yielded positive results in all patients. For example, tremor suppression was achieved both with stimulation delivered in an out-of-phase pattern with respect to the tremor, and with random timing of the stimulation. Overall, these results indicate that low-current stimulation of afferent fibers is a promising approach for tremor suppression, but that further research is required to identify how the effect can be maximized in the individual patient.
Publisher version (URL)http://dx.doi.org/10.3389/fnins.2017.00178
URIhttp://hdl.handle.net/10261/153077
DOI10.3389/fnins.2017.00178
ISSN1662-4548
Appears in Collections:(CAR) Artículos
(IC) Artículos
Files in This Item:
File Description SizeFormat 
Electrical Stimulation of Afferent Pathways.pdf1,2 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.