Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/153021
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Modification of Bacterial Effector Proteins Inside Eukaryotic Host Cells |
Autor: | Popa, Crina CSIC ORCID; Tabuchi, Mitsuaki; Valls, Marc CSIC ORCID | Fecha de publicación: | 20-jul-2016 | Editor: | Frontiers Media | Citación: | Front. Cell. Infect. Microbiol. 6: 73 (2016) | Resumen: | Pathogenic bacteria manipulate their hosts by delivering a number of virulence proteins -called effectors- directly into the plant or animal cells. Recent findings have shown that such effectors can suffer covalent modifications inside the eukaryotic cells. Here, we summarize the recent reports where effector modifications by the eukaryotic machinery have been described. We restrict our focus on proteins secreted by the type III or type IV systems, excluding other bacterial toxins. We describe the known examples of effectors whose enzymatic activity is triggered by interaction with plant and animal cell factors, including GTPases, E2-Ubiquitin conjugates, cyclophilin and thioredoxins. We focus on the structural interactions with these factors and their influence on effector function. We also review the described examples of host-mediated post-translational effector modifications which are required for proper subcellular location and function. These host-specific covalent modifications include phosphorylation, ubiquitination, SUMOylation, and lipidations such as prenylation, fatty acylation and phospholipid binding. | Versión del editor: | http://dx.doi.org/10.3389/fcimb.2016.00073 | URI: | http://hdl.handle.net/10261/153021 | DOI: | 10.3389/fcimb.2016.00073 | ISSN: | 2235-2988 |
Aparece en las colecciones: | (CRAG) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Modification of Bacterial Effector Proteins.pdf | 1,25 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
23
checked on 22-abr-2024
SCOPUSTM
Citations
38
checked on 16-abr-2024
WEB OF SCIENCETM
Citations
35
checked on 26-feb-2024
Page view(s)
271
checked on 23-abr-2024
Download(s)
188
checked on 23-abr-2024