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dc.contributor.authorBueno, Claraes_ES
dc.contributor.authorRoldan, Mares_ES
dc.contributor.authorAnguita, Eduardoes_ES
dc.contributor.authorRomero-Moya, Damiaes_ES
dc.contributor.authorMartín-Antonio, Beatrizes_ES
dc.contributor.authorRosu-Myles, Michaeles_ES
dc.contributor.authordel Cañizo, Consueloes_ES
dc.contributor.authorCampos, Franciscoes_ES
dc.contributor.authorGarcía, Reginaes_ES
dc.contributor.authorGómez-Casares, M. Teresaes_ES
dc.contributor.authorFuster, José Luises_ES
dc.contributor.authorJurado, Manueles_ES
dc.contributor.authorDelgado, M.es_ES
dc.contributor.authorMenéndez, Pabloes_ES
dc.date.accessioned2017-07-14T08:57:09Z-
dc.date.available2017-07-14T08:57:09Z-
dc.date.issued2014-07-
dc.identifier.citationHaematologica - the Hematology Journales_ES
dc.identifier.issn0390-6078-
dc.identifier.urihttp://hdl.handle.net/10261/152762-
dc.descriptionObtained from the Haematologica Journal website http://www.haematologica.orges_ES
dc.description.abstractAplastic anemia is a life-threatening bone marrow failure disorder characterized by peripheral pancytopenia and marrow hypoplasia. The majority of cases of aplastic anemia remain idiopathic, although hematopoietic stem cell deficiency and impaired immune responses are hallmarks underlying the bone marrow failure in this condition. Mesenchymal stem/stromal cells constitute an essential component of the bone marrow hematopoietic microenvironment because of their immunomodulatory properties and their ability to support hematopoiesis, and they have been involved in the pathogenesis of several hematologic malignancies. We investigated whether bone marrow mesenchymal stem cells contribute, directly or indirectly, to the pathogenesis of aplastic anemia. We found that mesenchymal stem cell cultures can be established from the bone marrow of aplastic anemia patients and display the same phenotype and differentiation potential as their counterparts from normal bone marrow. Mesenchymal stem cells from aplastic anemia patients support the in vitro homeostasis and the in vivo repopulating function of CD34+ cells, and maintain their immunosuppressive and anti-inflammatory properties. These data demonstrate that bone marrow mesenchymal stem cells from patients with aplastic anemia do not have impaired functional and immunological properties, suggesting that they do not contribute to the pathogenesis of the disease.es_ES
dc.description.sponsorshipAuthors thanks Fundacio Josep Carreras and Obra Social la Caixa for their financial support. This work was funded by Health Canada (H4084-112281 to PM and MR-M), the FIS/FEDER (PI10/00449 to PM and PI11/00119 to CB), the Spanish Association Against Cancer Foundation (CI110023 to PM) and Sandra Ibarra Foundation (to PM). CB is supported by a Miguel Servet contract (CP07/0059). DRM is supported by a PFIS scholarship (FI11/0511). PM, MD, CC and JLF are investigators of the Spanish Cell Therapy cooperative network (TERCEL).es_ES
dc.language.isoenges_ES
dc.publisherFerrata Storti Foundationes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rightsopenAccesses_ES
dc.subjectSTROMAL CELLSes_ES
dc.subjectHEMATOPOIETIC-CELLSes_ES
dc.subjectENDOTHELIAL-CELLSes_ES
dc.subjectENGRAFTMENTes_ES
dc.subjectTRANSPLANTATIONes_ES
dc.subjectTHAILANDes_ES
dc.subjectCOTRANSPLANTATIONes_ES
dc.subjectABNORMALITIESes_ES
dc.subjectEPIDEMIOLOGYes_ES
dc.subjectMAINTENANCEes_ES
dc.titleBone marrow mesenchymal stem cells from patients with aplastic anemia maintain functional and immune properties and do not contribute to the pathogenesis of the diseasees_ES
dc.typeartículoes_ES
dc.identifier.doi10.3324/haematol.2014.103580-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://www.haematologica.org/content/99/7/1168.longes_ES
dc.rights.licensehttp://www.haematologica.org/terms-conditionses_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.pmid24727813-
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