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Role of IGF-I in brown adipocytes proliferation and differentiation

Other TitlesPapel del IGF-I en la proliferación y diferenciación de los adipocitos marrones
AuthorsLorenzo, Margarita; Valverde, Ángela M.; Teruel, Teresa; Benito, Manuel
Issue Date1996
PublisherReal Academia Nacional de Farmacia (España)
CitationAnales de la Real Academia Nacional de Farmacia 62: 61-71 (1996)
AbstractFetal brown adipocyte in primary culture undergoes proliferation in the presence of IG-I and also induces the adipogenic-program related to lipid synthesis and the thermogenic-program associated with the expression of the uncoupling protein. Moreover, we have recently described an endogenous expression of IGF-I mRNA in brown adipose tissue at day 20 of fetal development and also an increase in the IGF-I receptor mRNA content at the end of the fetal life, which runs parallel to the onset of late tissue differentiation. Thus, IGF-I, in an autocrine/paracrine fashion may be a major signal involved in brown adipose tissue development prior to birth.
Identifiersissn: 1697-428X
Appears in Collections:(IIBM) Artículos
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