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dc.contributor.authorGonzález-Sarrías, Antonioes_ES
dc.contributor.authorNúñez-Sánchez, María Ángeleses_ES
dc.contributor.authorTomás Barberán, Franciscoes_ES
dc.contributor.authorEspín de Gea, Juan Carloses_ES
dc.date.accessioned2017-06-28T11:36:34Z-
dc.date.available2017-06-28T11:36:34Z-
dc.date.issued2016-11-14-
dc.identifier.citationJournal of agricultural and food chemistry 65: 752-758 (2017)es_ES
dc.identifier.issn0021-8561-
dc.identifier.urihttp://hdl.handle.net/10261/152143-
dc.description.abstractOxidative stress is involved in cell death in neurodegenerative diseases. Dietary polyphenols can exert health benefits, but their direct effects on neuronal cells are debatable because most phenolics are metabolized and do not reach the brain as they occur in the dietary sources. Herein, we evaluate the effects of a panel of bioavailable polyphenols and derived metabolites at physiologically relevant conditions against H2O2-induced apoptosis in human neuroblastoma SH-SY5Y cells. Among the 19 metabolites tested, 3,4-dihydroxyphenylpropionic acid, 3,4-dihydroxyphenylacetic acid, gallic acid, ellagic acid, and urolithins prevented neuronal apoptosis via attenuation of ROS levels, increased REDOX activity, and decreased oxidative stress-induced apoptosis by preventing the caspase-3 activation via the mitochondrial apoptotic pathway in SH-SY5Y cells. This suggests that dietary sources containing the polyphenol precursors of these molecules such as cocoa, berries, walnuts, and tea could be potential functional foods to reduce oxidative stress associated with the onset and progress of neurodegenerative diseases.es_ES
dc.description.sponsorshipThis work was funded by Projects CICYT AGL2011-22447, AGL2015-64124-R (MINECO, Spain), 201370E068 (CSIC, Spain), and BACCHUS (FP7-KBBE-2012-6-single stage, European Commission Grant Agreement 312090). A.G.-S. and M.A.N.-S. are holders of a “Juan de la Cierva” contract and an FPI grant, respectively, from MINECO.es_ES
dc.language.isoenges_ES
dc.publisherAmerican Chemical Societyes_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2015-64124-Res_ES
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/312090es_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rightsopenAccesses_ES
dc.subjectEllagic acides_ES
dc.subjectGallic acides_ES
dc.subjectNeuroprotective effectses_ES
dc.subjectPhenolic acidses_ES
dc.subjectPolyphenoles_ES
dc.subjectUrolithinses_ES
dc.titleNeuroprotective Effects of Bioavailable Polyphenol-Derived Metabolites against Oxidative Stress-Induced Cytotoxicity in Human Neuroblastoma SH-SY5Y Cellses_ES
dc.typeartículoes_ES
dc.identifier.doi10.1021/acs.jafc.6b04538-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://doi.org/10.1021/acs.jafc.6b04538es_ES
dc.identifier.e-issn1520-5118-
dc.rights.licensehttp://pubs.acs.org/page/policy/authorchoice_termsofuse.htmles_ES
dc.contributor.funderComisión Interministerial de Ciencia y Tecnología, CICYT (España)es_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderConsejo Superior de Investigaciones Científicas (España)es_ES
dc.contributor.funderEuropean Commissiones_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100007273es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003339es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
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