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dc.contributor.authorHerboso, Leirees_ES
dc.contributor.authorOliveira, Marisaes_ES
dc.contributor.authorTalamillo, Anaes_ES
dc.contributor.authorPérez, Coraliaes_ES
dc.contributor.authorGonzález, Monikaes_ES
dc.contributor.authorMartín Casacuberta, David A.es_ES
dc.contributor.authorSutherland, James D.es_ES
dc.contributor.authorShingleton, Alexander W.es_ES
dc.contributor.authorMirth, Christenes_ES
dc.contributor.authorBarrio, Rosaes_ES
dc.identifier.citationScientific Reports 5: 12383 (2015)es_ES
dc.description.abstractAnimals have a determined species-specific body size that results from the combined action of hormones and signaling pathways regulating growth rate and duration. In Drosophila, the steroid hormone ecdysone controls developmental transitions, thereby regulating the duration of the growth period. Here we show that ecdysone promotes the growth of imaginal discs in mid-third instar larvae, since imaginal discs from larvae with reduced or no ecdysone synthesis are smaller than wild type due to smaller and fewer cells. We show that insulin-like peptides are produced and secreted normally in larvae with reduced ecdysone synthesis, and upstream components of insulin/insulin-like signaling are activated in their discs. Instead, ecdysone appears to regulate the growth of imaginal discs via Thor/4E-BP, a negative growth regulator downstream of the insulin/insulin-like growth factor/Tor pathways. Discs from larvae with reduced ecdysone synthesis have elevated levels of Thor, while mutations in Thor partially rescue their growth. The regulation of organ growth by ecdysone is evolutionarily conserved in hemimetabolous insects, as shown by our results obtained using Blattella germanica. In summary, our data provide new insights into the relationship between components of the insulin/insulin-like/Tor and ecdysone pathways in the control of organ growth.es_ES
dc.description.sponsorshipRB, DM and LH thank the Spanish Ministry of Science and Consolider program (BFU-2008-01884, BFU2011-25986, CSD2007-008-25120, BFU2009-10571 and BES-2009-016077). RB thanks the Departments of Education and Industry of the Basque Government (PI2012/42), and the Bizkaia County. CKM and MMO thank the Instituto Gulbenkian de Ciência/Fundação Calouste Gulbenkian and the Fundação Para a Ciência e a Tecnologia (SFRH/BD/51181/2010). AWS thanks the National Science Foundation (IOS-0919855 and IOS-1406547).es_ES
dc.publisherNature Publishing Groupes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.titleEcdysone promotes growth of imaginal discs through the regulation of Thor in D. melanogasteres_ES
dc.description.peerreviewedPeer reviewedes_ES
dc.contributor.funderMinisterio de Ciencia e Innovación (España)es_ES
dc.contributor.funderEusko Jaurlaritzaes_ES
dc.contributor.funderFundação Calouste Gulbenkianes_ES
dc.contributor.funderFundação para a Ciência e a Tecnologia (Portugal)es_ES
dc.contributor.funderNational Science Foundation (US)es_ES
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