English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/151156
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Circuit-specific signaling in astrocyte-neuron networks in basal ganglia pathways

AuthorsMartín, R.; Bajo-Grañeras, Raquel; Moratalla, Rosario ; Perea, Gertrudis ; Araque, Alfonso
Keywordssynapses
Astrocytes
Issue Date2015
CitationScience 349: 730- 734 (2015)
Abstract© 2015, American Association for the Advancement of Science. All rights reserved. Astrocytes are important regulatory elements in brain function. They respond to neurotransmitters and release gliotransmitters that modulate synaptic transmission. However, the cell- and synapse-specificity of the functional relationship between astrocytes and neurons in certain brain circuits remains unknown. In the dorsal striatum, which mainly comprises two intermingled subtypes (striatonigral and striatopallidal) of medium spiny neurons (MSNs) and synapses belonging to two neural circuits (the direct and indirect pathways of the basal ganglia), subpopulations of astrocytes selectively responded to specific MSN subtype activity. These subpopulations of astrocytes released glutamate that selectively activated N-methyl-D-aspartate receptors in homotypic, but not heterotypic, MSNs. Likewise, astrocyte subpopulations selectively regulated homotypic synapses through metabotropic glutamate receptor activation. Therefore, bidirectional astrocyte-neuron signaling selectively occurs between specific subpopulations of astrocytes, neurons, and synapses.
URIhttp://hdl.handle.net/10261/151156
DOI10.1126/science.aaa7945
Identifiersdoi: 10.1126/science.aaa7945
issn: 1095-9203
Appears in Collections:(IC) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.