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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/150920
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dc.contributor.authorNúñez, O.-
dc.contributor.authorMoreno-Bueno, Gema-
dc.contributor.authorEsteller, Manel-
dc.contributor.authorPollán, Marina-
dc.contributor.authorPujana, Miguel Ángel-
dc.date.accessioned2017-06-05T12:03:11Z-
dc.date.available2017-06-05T12:03:11Z-
dc.date.issued2016-
dc.identifierdoi: 10.1007/s10549-016-3737-8-
dc.identifiere-issn: 1573-7217-
dc.identifierissn: 0167-6806-
dc.identifier.citationBreast Cancer Research and Treatment 156(1): 195-201 (2016)-
dc.identifier.urihttp://hdl.handle.net/10261/150920-
dc.descriptionThis article is published with open access at Springerlink.com.-- et al.-
dc.description.abstractMolecular evidence has linked the pathophysiology of lymphangioleiomyomatosis (LAM) to that of metastatic breast cancer. Following on this observation, we assessed the association between LAM and subsequent breast cancer. An epidemiological study was carried out using three LAM country cohorts, from Japan, Spain, and the United Kingdom. The number of incident breast cancer cases observed in these cohorts was compared with the number expected on the basis of the country-specific incidence rates for the period 2000–2014. Immunohistochemical studies and exome sequence analysis were performed in two and one tumors, respectively. All cohorts revealed breast cancer standardized incidence ratios (SIRs) ≥ 2.25. The combined analysis of all cases or restricted to pre-menopausal age groups revealed significantly higher incidence of breast cancer: SIR = 2.81, 95 % confidence interval (CI) = 1.32–5.57, P = 0.009; and SIR = 4.88, 95 % CI = 2.29–9.99, P = 0.0007, respectively. Immunohistochemical analyses showed positivity for known markers of lung metastatic potential. This study suggests the existence of increased breast cancer risk among LAM patients. Prospective studies may be warranted to corroborate this result, which may be particularly relevant for pre-menopausal women with LAM.-
dc.description.sponsorshipWe wish to thank all patients for their contribution to the work of the corresponding centers, clinics, or foundations and owe particular thanks to the Spanish Association of LAM (AELAM) for continuous support during the study.-
dc.publisherSpringer Nature-
dc.relation.isversionofPublisher's version-
dc.rightsopenAccess-
dc.subjectTSC2-
dc.subjectTSC1-
dc.subjectmTOR-
dc.subjectBreast cancer-
dc.subjectIncidence-
dc.subjectLymphangioleiomyomatosis-
dc.titleStudy of breast cancer incidence in patients of lymphangioleiomyomatosis-
dc.typeartículo-
dc.identifier.doi10.1007/s10549-016-3737-8-
dc.relation.publisherversionhttps://doi.org/10.1007/s10549-016-3737-8-
dc.date.updated2017-06-05T12:03:11Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.rights.licensehttp://creativecommons.org/licenses/by-nc/4.0/-
dc.contributor.funderAsociación Española de Linfangioleiomiomatosis-
dc.relation.csicSí-
dc.identifier.pmid26951504-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.cerifentitytypePublications-
item.openairetypeartículo-
item.grantfulltextopen-
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