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Title

Study of breast cancer incidence in patients of lymphangioleiomyomatosis

AuthorsNúñez, O.; Moreno-Bueno, Gema ; Esteller, Manel; Pollán, Marina; Pujana, Miguel Ángel
KeywordsTSC2
TSC1
mTOR
Breast cancer
Incidence
Lymphangioleiomyomatosis
Issue Date2016
PublisherSpringer
CitationBreast Cancer Research and Treatment 156(1): 195-201 (2016)
AbstractMolecular evidence has linked the pathophysiology of lymphangioleiomyomatosis (LAM) to that of metastatic breast cancer. Following on this observation, we assessed the association between LAM and subsequent breast cancer. An epidemiological study was carried out using three LAM country cohorts, from Japan, Spain, and the United Kingdom. The number of incident breast cancer cases observed in these cohorts was compared with the number expected on the basis of the country-specific incidence rates for the period 2000–2014. Immunohistochemical studies and exome sequence analysis were performed in two and one tumors, respectively. All cohorts revealed breast cancer standardized incidence ratios (SIRs) ≥ 2.25. The combined analysis of all cases or restricted to pre-menopausal age groups revealed significantly higher incidence of breast cancer: SIR = 2.81, 95 % confidence interval (CI) = 1.32–5.57, P = 0.009; and SIR = 4.88, 95 % CI = 2.29–9.99, P = 0.0007, respectively. Immunohistochemical analyses showed positivity for known markers of lung metastatic potential. This study suggests the existence of increased breast cancer risk among LAM patients. Prospective studies may be warranted to corroborate this result, which may be particularly relevant for pre-menopausal women with LAM.
DescriptionThis article is published with open access at Springerlink.com.-- et al.
Publisher version (URL)https://doi.org/10.1007/s10549-016-3737-8
URIhttp://hdl.handle.net/10261/150920
DOI10.1007/s10549-016-3737-8
Identifiersdoi: 10.1007/s10549-016-3737-8
e-issn: 1573-7217
issn: 0167-6806
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