English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/150750
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Clinical relevance of colorectal cancer molecular subtypes

AuthorsRodríguez, Nuria ; Domínguez, Gemma; Barderas, Rodrigo ; Mendiola, Marta
KeywordsMolecular subtypes
Personalized treatment
Colorectal cancer
Issue Date2017
PublisherElsevier
CitationCritical Reviews in Oncology/Hematology 109: 9-19 (2017)
AbstractColorectal cancer (CRC) is characterized by alteration of critical pathways such TP53 inactivation, BRAF, PI3CA mutations, APC inactivation, KRAS, TGF-β, CTNNB mutations, disregulation of Epithelial to mesnechymal transition (EMT) genes, WNT signaling activation, MYC amplification, and others. Differences in these molecular events results in differences in phenotypic characteristics of CRC, that have been studied and classified by different models of molecular subtypes. It could have potential applications to prognosis, but also to therapeutical approaches of the CRC patients. We review and summarized the different molecular classifications and try to clarify their clinical and therapeutical relevance.
URIhttp://hdl.handle.net/10261/150750
DOI10.1016/j.critrevonc.2016.11.007
Identifiersdoi: 10.1016/j.critrevonc.2016.11.007
e-issn: 1879-0461
issn: 1040-8428
Appears in Collections:(IIBM) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.