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dc.contributor.authorAbalo, Raquel-
dc.contributor.authorUranga-Ocio, José Antonio-
dc.contributor.authorGirón, Rocío-
dc.contributor.authorVera, Gema-
dc.contributor.authorLópez-Pérez, Ana E.-
dc.contributor.authorMartín, M. Isabel-
dc.identifierdoi: 10.1111/nmo.12952-
dc.identifiere-issn: 1365-2982-
dc.identifierissn: 1350-1925-
dc.identifier.citationNeurogastroenterology and Motility 29(3): e12952 (2017)-
dc.description.abstract[Background]: The antineoplastic drug 5-fluoruracil (5-FU) is a pirimidine analog, which frequently induces potentially fatal diarrhea and mucositis. Cannabinoids reduce gastrointestinal motility and secretion and might prevent 5-FU-induced gut adverse effects. Here, we asked whether cannabinoids may prevent diarrhea and mucositis induced by 5-FU in the rat. [Methods]: Male Wistar rats received vehicle or the non-selective cannabinoid agonist WIN 55,212-2 (WIN; 0.5 mg kg injection, 1 injection day, 4 consecutive days) by intraperitoneal (ip) route; on the first 2 days, animals received also saline or 5-FU (150 mg kg injection, cumulative dose of 300 mg kg). Gastrointestinal motor function was radiographically studied after barium contrast intragastric administration on experimental days 1 and 4. Structural alterations of the stomach, small intestine and colon were histologically studied on day 4. PAS staining and immunohistochemistry for Ki67, chromogranin A and CD163 were used to detect secretory, proliferating, and endocrine cells, and activated macrophages respectively. [Key Results]: As shown radiographically, 5-FU induced significant gastric emptying delay (on days 1 and 4) and diarrhea (on day 4). WIN did not significantly alter the motility curves obtained for either control or 5-FU-treated animals but tended to reduce the severity of 5-FU-induced diarrhea and increased permanence of barium from day 1 to the beginning of day 4 in 5-FU-treated animals. 5-FU-induced mucositis was severe and not counteracted by WIN. [Conclusions and Inferences]: 5-FU-induced diarrhea, but not mucositis, was partly prevented by WIN at a low dose. Cannabinoids might be useful to prevent chemotherapy-induced diarrhea.-
dc.description.sponsorshipThis work was supported by Ministerio de Educación y Ciencia (SAF201-40075-C02-01) and Comunidad de Madrid (S2010/BMD-2308).-
dc.publisherJohn Wiley & Sons-
dc.subjectGastrointestinal motility-
dc.subjectChemotherapy-induced adverse effects-
dc.titleMay cannabinoids prevent the development of chemotherapy-induced diarrhea and intestinal mucositis? Experimental study in the rat-
dc.description.versionPeer Reviewed-
dc.contributor.funderComunidad de Madrid-
dc.contributor.funderMinisterio de Educación y Ciencia (España)-
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