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Title

Egg white-derived peptides prevent male reproductive dysfunction induced by mercury in rats

AuthorsRizzetti, Danize Aparecida; Martinez, Caroline S.; Uranga-Ocio, José Antonio; Miguel, Marta ; Wiggers, Giulia Alessandra
KeywordsMercury
Oxidative stress
Sperm quality
Functional food
Antioxidant property
Male reproductive dysfunction
Issue Date2017
PublisherElsevier
CitationFood and Chemical Toxicology 100: 253-264 (2017)
AbstractOxidative stress in known to contribute to the male reproductive dysfunction induced by mercury (Hg). Our study tested the hypothesis that the egg white hydrolysate (EWH), a potent antioxidant in vitro, is able to prevent the effects of prolonged Hg exposure on male reproductive system in rats. For this, rats were treated for 60 days with: a) Untreated - saline solution (i.m.); b) Hydrolysate - EWH (1 g/kg/day, gavage); c) Mercury - HgCl (1st dose 4.6 μg/kg, subsequent doses 0.07 μg/kg/day, i.m.); d) Hydrolysate-Mercury. At the end of the treatment, sperm motility, count and morphological studies were performed; Reactive Oxygen Species (ROS) levels, lipid peroxidation, antioxidant capacity, histological and immunohistochemical assays on testis and epididymis were also carried out. As results, HgCl-treatment decreased sperm number, increased sperm transit time in epididymis and impaired sperm morphology. However, these harmful effects were prevented by EWH. HgCl-treatment also increased ROS levels, lipid peroxidation and antioxidant capacity in testis and epididymis as well as promoted testicular inflammation and histological changes in epididymis. EWH improved histological and immunohistochemical alterations, probably due to its antioxidant property. In conclusion, the EWH could represent a powerful natural alternative to protect the male reproductive system against Hg-induced sperm toxicity.
URIhttp://hdl.handle.net/10261/150579
DOI10.1016/j.fct.2016.12.038
Identifiersdoi: 10.1016/j.fct.2016.12.038
e-issn: 1873-6351
issn: 0278-6915
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