English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/150574
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Effects of milk casein hydrolyzate supplemented with phytosterols on hypertension and lipid profile in hypercholesterolemic hypertensive rats

AuthorsFerreira Santos, Pedro; Carrón, Rosalía; Recio, Isidra ; Sevilla, Mª Ángeles; Montero, Mª José
Casein hydrolyzate
Issue Date2017
CitationJournal of Functional Foods 28: 168-176 (2017)
AbstractThis study investigates the beneficial effect of a milk casein hydrolyzate supplemented with phytosterols in hypercholesterolemic hypertensive rats. Spontaneously hypertensive rats were fed for 8 weeks with standard diet, or high cholesterol diet alone and supplemented with casein hydrolyzate or casein hydrolyzate plus phytosterols. Blood pressure was measured by tail-cuff method, vascular reactivity was performed on isolated aorta and biochemical parameters were evaluated in plasma. The hypercholesterolemic diet caused elevation of total cholesterol, low-density lipoprotein cholesterol, atherogenic index, lipid peroxidation, liver size and hepatic steatosis accompanied with a severe reduction of high-density lipoprotein cholesterol. The treatment with the casein hydrolyzate reduced blood pressure, cardiac hypertrophy and oxidative stress, and improved the endothelial function. The incorporation of phytosterols prevented the changes caused by the hypercholesterolemic diet and increased the antioxidant effect of casein hydrolyzate. In conclusion, treatment with milk casein hydrolyzate supplemented with phytosterols provides benefits when coexisting hypertension and hypercholesterolemia.
Publisher version (URL)https://doi.org/10.1016/j.jff.2016.11.020
Identifiersdoi: 10.1016/j.jff.2016.11.020
issn: 1756-4646
e-issn: 2214-9414
Appears in Collections:(CIAL) Artículos
Files in This Item:
File Description SizeFormat 
effectsofmilkcasein.pdf498,81 kBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.