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Title

Effects of milk casein hydrolyzate supplemented with phytosterols on hypertension and lipid profile in hypercholesterolemic hypertensive rats

AuthorsFerreira Santos, Pedro; Carrón, Rosalía; Recio, Isidra ; Sevilla, Mª Ángeles; Montero, Mª José
KeywordsHypertension
Phytosterols
Hypercholesterolemia
SHR
Casein hydrolyzate
Issue Date2017
PublisherElsevier
CitationJournal of Functional Foods 28: 168-176 (2017)
AbstractThis study investigates the beneficial effect of a milk casein hydrolyzate supplemented with phytosterols in hypercholesterolemic hypertensive rats. Spontaneously hypertensive rats were fed for 8 weeks with standard diet, or high cholesterol diet alone and supplemented with casein hydrolyzate or casein hydrolyzate plus phytosterols. Blood pressure was measured by tail-cuff method, vascular reactivity was performed on isolated aorta and biochemical parameters were evaluated in plasma. The hypercholesterolemic diet caused elevation of total cholesterol, low-density lipoprotein cholesterol, atherogenic index, lipid peroxidation, liver size and hepatic steatosis accompanied with a severe reduction of high-density lipoprotein cholesterol. The treatment with the casein hydrolyzate reduced blood pressure, cardiac hypertrophy and oxidative stress, and improved the endothelial function. The incorporation of phytosterols prevented the changes caused by the hypercholesterolemic diet and increased the antioxidant effect of casein hydrolyzate. In conclusion, treatment with milk casein hydrolyzate supplemented with phytosterols provides benefits when coexisting hypertension and hypercholesterolemia.
Publisher version (URL)https://doi.org/10.1016/j.jff.2016.11.020
URIhttp://hdl.handle.net/10261/150574
DOI10.1016/j.jff.2016.11.020
Identifiersdoi: 10.1016/j.jff.2016.11.020
issn: 1756-4646
e-issn: 2214-9414
Appears in Collections:(CIAL) Artículos
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