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Título: | Aurora a drives early signalling and vesicle dynamics during T-cell activation |
Autor: | Blas-Rus, Noelia; Alarcón, Balbino CSIC ORCID; Sánchez-Madrid, Francisco | Fecha de publicación: | 19-abr-2016 | Editor: | Nature Publishing Group | Citación: | Nature Communications 7: 11389 (2016) | Resumen: | Aurora A is a serine/threonine kinase that contributes to the progression of mitosis by inducing microtubule nucleation. Here we have identified an unexpected role for Aurora A kinase in antigen-driven T-cell activation. We find that Aurora A is phosphorylated at the immunological synapse (IS) during TCR-driven cell contact. Inhibition of Aurora A with pharmacological agents or genetic deletion in human or mouse T cells severely disrupts the dynamics of microtubules and CD3¿-bearing vesicles at the IS. The absence of Aurora A activity also impairs the activation of early signalling molecules downstream of the TCR and the expression of IL-2, CD25 and CD69. Aurora A inhibition causes delocalized clustering of Lck at the IS and decreases phosphorylation levels of tyrosine kinase Lck, thus indicating Aurora A is required for maintaining Lck active. These findings implicate Aurora A in the propagation of the TCR activation signal. | URI: | http://hdl.handle.net/10261/150537 | DOI: | 10.1038/ncomms11389 | Identificadores: | doi: 10.1038/ncomms11389 issn: 2041-1723 |
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AlarconB_AuroraADrivesEarlySignalling.pdf | 4,52 MB | Adobe PDF | Visualizar/Abrir |
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