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Title

Aurora a drives early signalling and vesicle dynamics during T-cell activation

AuthorsBlas-Rus, Noelia; Alarcón, Balbino ; Sánchez-Madrid, Francisco
Issue Date19-Apr-2016
PublisherNature Publishing Group
CitationNature Communications 7: 11389 (2016)
AbstractAurora A is a serine/threonine kinase that contributes to the progression of mitosis by inducing microtubule nucleation. Here we have identified an unexpected role for Aurora A kinase in antigen-driven T-cell activation. We find that Aurora A is phosphorylated at the immunological synapse (IS) during TCR-driven cell contact. Inhibition of Aurora A with pharmacological agents or genetic deletion in human or mouse T cells severely disrupts the dynamics of microtubules and CD3¿-bearing vesicles at the IS. The absence of Aurora A activity also impairs the activation of early signalling molecules downstream of the TCR and the expression of IL-2, CD25 and CD69. Aurora A inhibition causes delocalized clustering of Lck at the IS and decreases phosphorylation levels of tyrosine kinase Lck, thus indicating Aurora A is required for maintaining Lck active. These findings implicate Aurora A in the propagation of the TCR activation signal.
URIhttp://hdl.handle.net/10261/150537
DOI10.1038/ncomms11389
Identifiersdoi: 10.1038/ncomms11389
issn: 2041-1723
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