Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/150506
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Mecha, Miriam | - |
dc.contributor.author | Feliú, Ana | - |
dc.contributor.author | Ínigo, Paula M. | - |
dc.contributor.author | Mestre, Leyre | - |
dc.contributor.author | Carrillo-Salinas, F. J. | - |
dc.contributor.author | Guaza, Carmen | - |
dc.date.accessioned | 2017-05-26T11:35:10Z | - |
dc.date.available | 2017-05-26T11:35:10Z | - |
dc.date.issued | 2013-11 | - |
dc.identifier | doi: 10.1016/j.nbd.2013.06.016 | - |
dc.identifier | issn: 0969-9961 | - |
dc.identifier.citation | Neurobiology of Disease 59: 141-150 (2013) | - |
dc.identifier.uri | http://hdl.handle.net/10261/150506 | - |
dc.description.abstract | Inflammation in the central nervous system (CNS) is a complex process that involves a multitude of molecules and effectors, and it requires the transmigration of blood leukocytes across the blood-brain barrier (BBB) and the activation of resident immune cells. Cannabidiol (CBD), a non-psychotropic cannabinoid constituent of Cannabis sativa, has potent anti-inflammatory and immunosuppressive properties. Yet, how this compound modifies the deleterious effects of inflammation in TMEV-induced demyelinating disease (TMEV-IDD) remains unknown. Using this viral model of multiple sclerosis (MS), we demonstrate that CBD decreases the transmigration of blood leukocytes by downregulating the expression of vascular cell adhesion molecule-1 (VCAM-1), chemokines (CCL2 and CCL5) and the proinflammatory cytokine IL-1β, as well as by attenuating the activation of microglia. Moreover, CBD administration at the time of viral infection exerts long-lasting effects, ameliorating motor deficits in the chronic phase of the disease in conjunction with reduced microglial activation and pro-inflammatory cytokine production. Adenosine A2A receptors participate in some of the anti-inflammatory effects of CBD, as the A2A antagonist ZM241385 partially blocks the protective effects of CBD in the initial stages of inflammation. Together, our findings highlight the anti-inflammatory effects of CBD in this viral model of MS and demonstrate the significant therapeutic potential of this compound for the treatment of pathologies with an inflammatory component. © 2013 The Authors. | - |
dc.publisher | Academic Press | - |
dc.rights | closedAccess | - |
dc.subject | CCL5 | - |
dc.subject | very late antigen-4 | - |
dc.subject | tetrahydrocannabinol | - |
dc.subject | Multiple sclerosis | - |
dc.subject | experimental autoimmune encephalomyelitis | - |
dc.subject | chemokine receptor 2 | - |
dc.subject | Adenosine | - |
dc.subject | BBB | - |
dc.subject | CBD | - |
dc.subject | CCL2 | - |
dc.subject | CCR2 | - |
dc.subject | CNS | - |
dc.subject | Cannabidiol | - |
dc.subject | Chemokines | - |
dc.subject | EAE | - |
dc.subject | Infiltrates | - |
dc.subject | Inflammation | - |
dc.subject | MS | - |
dc.subject | Microglia | - |
dc.subject | Multiple sclerosis | - |
dc.subject | THC | - |
dc.subject | TMEV-IDD | - |
dc.subject | Theiler's murine encephalomyelitis virus | - |
dc.subject | Theiler's murine encephalomyelitis virus-induced demyelinating disease | - |
dc.subject | VCAM-1 | - |
dc.subject | VLA-4 | - |
dc.subject | Blood brain barrier | - |
dc.subject | Cannabidiol | - |
dc.subject | Central nervous system | - |
dc.subject | chemokine ligand 2 | - |
dc.subject | chemokine ligand 5 | - |
dc.title | Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: A role for A2A receptors | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1016/j.nbd.2013.06.016 | - |
dc.relation.publisherversion | http://doi.org/10.1016/j.nbd.2013.06.016 | - |
dc.date.updated | 2017-05-26T11:35:10Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.relation.csic | Sí | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
Aparece en las colecciones: | (IC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
205
checked on 03-abr-2024
WEB OF SCIENCETM
Citations
185
checked on 29-feb-2024
Page view(s)
335
checked on 18-abr-2024
Download(s)
92
checked on 18-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.