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dc.contributor.authorElshaer, Nashwaes_ES
dc.contributor.authorPiulachs, Maria-Dolorses_ES
dc.identifier.citationBiology of the Cell 107(8): 273-285 (2015)es_ES
dc.description.abstract[Background information] Epidermal growth factor receptor (EGFR) signalling is crucial for the regulation of multiple developmental processes. Its function in relation to insect oogenesis has been thoroughly studied in the fly Drosophila melanogaster, which possesses ovaries of the highly modified meroistic type. Conversely, studies in other insect species with different ovary types are scarce. We have studied EGFR functions in the oogenesis of the cockroach Blattella germanica, a phylogenetically basal insect with panoistic ovaries.es_ES
dc.description.abstract[Results] In this cockroach, depletion of EGFR expression aborts oocyte maturation and prevents oviposition, as affects the distribution of F-actins in the follicular cells of the basal ovarian follicle, which triggers premature apoptosis. In the younger ovarian follicles within the ovariole, depletion of EGFR expression reduces the number of follicular cells, possibly because the Hippo pathway is altered; moreover, the concomitant reduction of Notch expression results in the absence of stalk. Finally, depletion of EGFR determines an increase in the number of germinal cells.es_ES
dc.description.abstract[Conclusions] In the panoistic ovary of B. germanica, EGFR plays a role in the control of cell proliferation through interaction with Hippo and Notch pathways.es_ES
dc.description.sponsorshipSupport for this research was provided by the Spanish Ministry of Science and Innovation [Grant. BFU2011-22404], and from the Secretaria d'Universitats i Recerca del Departament d'Economia i Coneixement de la Generalitat de Catalunya [2014 SGR 619]. N.E. received a pre-doctoral research grant (JAE-Pre) from the CSIC, and The European Social Fund (ESF).es_ES
dc.publisherJohn Wiley & Sonses_ES
dc.subjectBlattella germanicaes_ES
dc.subjectDrosophila melanogasteres_ES
dc.subjectEpidermal growth factores_ES
dc.subjectFollicular cellses_ES
dc.subjectInsect reproductiones_ES
dc.titleCrosstalk of EGFR signalling with Notch and Hippo pathways to regulate cell specification, migration and proliferation in cockroach panoistic ovarieses_ES
dc.description.peerreviewedPeer reviewedes_ES
dc.contributor.funderMinisterio de Ciencia e Innovación (España)es_ES
dc.contributor.funderGeneralitat de Catalunyaes_ES
dc.contributor.funderConsejo Superior de Investigaciones Científicas (España)es_ES
dc.contributor.funderEuropean Commissiones_ES
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