English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/150491
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

Crosstalk of EGFR signalling with Notch and Hippo pathways to regulate cell specification, migration and proliferation in cockroach panoistic ovaries

AuthorsElshaer, Nashwa; Piulachs, Maria-Dolors
KeywordsBlattella germanica
Drosophila melanogaster
Epidermal growth factor
Follicular cells
Insect reproduction
Issue DateAug-2015
PublisherJohn Wiley & Sons
CitationBiology of the Cell 107(8): 273-285 (2015)
Abstract[Background information] Epidermal growth factor receptor (EGFR) signalling is crucial for the regulation of multiple developmental processes. Its function in relation to insect oogenesis has been thoroughly studied in the fly Drosophila melanogaster, which possesses ovaries of the highly modified meroistic type. Conversely, studies in other insect species with different ovary types are scarce. We have studied EGFR functions in the oogenesis of the cockroach Blattella germanica, a phylogenetically basal insect with panoistic ovaries.
[Results] In this cockroach, depletion of EGFR expression aborts oocyte maturation and prevents oviposition, as affects the distribution of F-actins in the follicular cells of the basal ovarian follicle, which triggers premature apoptosis. In the younger ovarian follicles within the ovariole, depletion of EGFR expression reduces the number of follicular cells, possibly because the Hippo pathway is altered; moreover, the concomitant reduction of Notch expression results in the absence of stalk. Finally, depletion of EGFR determines an increase in the number of germinal cells.
[Conclusions] In the panoistic ovary of B. germanica, EGFR plays a role in the control of cell proliferation through interaction with Hippo and Notch pathways.
Publisher version (URL)http://dx.doi.org/10.1111/boc.201500003
URIhttp://hdl.handle.net/10261/150491
DOI10.1111/boc.201500003
ISSN0248-4900
E-ISSN1768-322X
Appears in Collections:(IBE) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.