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Título: | Novel peptides derived from αs1-casein with opioid activity and mucin stimulatory effect on HT29-MTX cells |
Autor: | Fernández-Tomé, Samuel CSIC ORCID; Martínez-Maqueda, D. CSIC ORCID; Girón, Rocío CSIC ORCID; Goicoechea, Carlos CSIC ORCID; Miralles, Beatriz CSIC ORCID ; Recio, Isidra CSIC ORCID | Palabras clave: | Goblet cells Opioid peptide Mucin Molecular dynamics µ-Opioid receptor |
Fecha de publicación: | 2016 | Editor: | Elsevier | Citación: | Journal of Functional Foods 25: 466-476 (2016) | Resumen: | The opioid effect of α-casein fragments related to AYFYPEL and YFYPEL, which had previously shown mucin-stimulatory activity in human goblet cells, was investigated. Peptides YFYPEL and YFYPE showed opioid agonistic activity in guinea pig ileum, and in mouse vas deferens but to a lower extent. Peptides were partly hydrolysed during the assay and several of the resulting fragments lost the N-terminal Tyr residue. Docking of peptides YFYPEL (active) and YFYP (inactive) into the active site of the opioid receptor model showed remarkable differences regarding the flexibility at the third intracellular loop of the receptor and the interaction with Pro at the peptide C-terminus that forced residues Arg and Glu from the receptor to move towards the interior of the binding pocket. The study on human cells HT29-MTX has shown that YFYPEL is the minimum fragment able to stimulate MUC5AC expression. | Versión del editor: | https://doi.org/10.1016/j.jff.2016.06.023 | URI: | http://hdl.handle.net/10261/150416 | DOI: | 10.1016/j.jff.2016.06.023 | Identificadores: | doi: 10.1016/j.jff.2016.06.023 issn: 1756-4646 e-issn: 2214-9414 |
Aparece en las colecciones: | (CIAL) Artículos (IQM) Artículos |
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HT29-MTXcells.pdf | 540,67 kB | Adobe PDF | Visualizar/Abrir |
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