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http://hdl.handle.net/10261/150171
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Title: | Estradiol meets notch signaling in developing neurons |
Authors: | Arévalo, María Ángeles ![]() ![]() |
Keywords: | estrogen receptors dendritogenesis hairy and enhancer of split neurogenin 3 G protein-coupled receptor 30 G protein-coupled estrogen receptor |
Issue Date: | 2010 |
Publisher: | Frontiers Media |
Citation: | Frontiers in Endocrinology 2 (2010) |
Abstract: | The transmembrane receptor Notch, a master developmental regulator, controls gliogene- sis, neurogenesis, and neurite development in the nervous system. Estradiol, acting as a hormonal signal or as a neurosteroid, also regulates these developmental processes. Here we review recent evidence indicating that estradiol and Notch signaling interact in devel- oping hippocampal neurons by a mechanism involving the putative membrane receptor G protein-coupled receptor 30.This interaction is relevant for the control of neuronal differen- tiation, since the downregulation of Notch signaling by estradiol results in the upregulation of neurogenin 3, which in turn promotes dendritogenesis. © 2011 Arevalo, Ruiz-Palmero, Simon-Areces, Acaz-Fonseca, Azcoitia and Garcia-Segura. |
URI: | http://hdl.handle.net/10261/150171 |
DOI: | 10.3389/fendo.2011.00021 |
Identifiers: | doi: 10.3389/fendo.2011.00021 issn: 1664-2392 |
Appears in Collections: | (IC) Artículos |
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Frontiers in Endocrinology.pdf | 1,72 MB | Adobe PDF | ![]() View/Open |
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