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Estradiol meets notch signaling in developing neurons

AuthorsArévalo, María Ángeles ; Ruiz-Palmero, Isabel; Simón-Areces, Julia; Acaz-Fonseca, E.; Azcoitia, I.; García-Segura, Luis M.
Keywordsestrogen receptors
hairy and enhancer of split
neurogenin 3
G protein-coupled receptor 30
G protein-coupled estrogen receptor
Issue Date2010
PublisherFrontiers Media
CitationFrontiers in Endocrinology 2 (2010)
AbstractThe transmembrane receptor Notch, a master developmental regulator, controls gliogene- sis, neurogenesis, and neurite development in the nervous system. Estradiol, acting as a hormonal signal or as a neurosteroid, also regulates these developmental processes. Here we review recent evidence indicating that estradiol and Notch signaling interact in devel- oping hippocampal neurons by a mechanism involving the putative membrane receptor G protein-coupled receptor 30.This interaction is relevant for the control of neuronal differen- tiation, since the downregulation of Notch signaling by estradiol results in the upregulation of neurogenin 3, which in turn promotes dendritogenesis. © 2011 Arevalo, Ruiz-Palmero, Simon-Areces, Acaz-Fonseca, Azcoitia and Garcia-Segura.
Identifiersdoi: 10.3389/fendo.2011.00021
issn: 1664-2392
Appears in Collections:(IC) Artículos
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