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http://hdl.handle.net/10261/150002
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dc.contributor.author | Ramírez de Molina, Ana | - |
dc.contributor.author | Vargas, Teodoro | - |
dc.contributor.author | Molina, Susana | - |
dc.contributor.author | González-Vallinas, Margarita | - |
dc.contributor.author | Martín-Hernández, Roberto | - |
dc.contributor.author | Sánchez-Martínez, Ruth | - |
dc.contributor.author | Dávalos Herrera, Alberto | - |
dc.contributor.author | González-Sarrías, Antonio | - |
dc.contributor.author | Espín de Gea, Juan Carlos | - |
dc.contributor.author | Tomás Barberán, Francisco | - |
dc.contributor.author | Reglero, Guillermo | - |
dc.date.accessioned | 2017-05-19T09:57:41Z | - |
dc.date.available | 2017-05-19T09:57:41Z | - |
dc.date.issued | 2015 | - |
dc.identifier | doi: 10.1124/jpet.114.221796 | - |
dc.identifier | e-issn: 1521-0103 | - |
dc.identifier | issn: 0022-3565 | - |
dc.identifier.citation | Journal of Pharmacology and Experimental Therapeutics 353(2): 433-444 (2015) | - |
dc.identifier.uri | http://hdl.handle.net/10261/150002 | - |
dc.description.abstract | Ellagic acid (EA) and some derivatives have been reported to inhibit cancer cell proliferation, induce cell cycle arrest, and modulate some important cellular processes related to cancer. This study aimed to identify possible structure-activity relationships of EA and some in vivo derivatives in their antiproliferative effect on both human colon cancer and normal cells, and to compare this activity with that of other polyphenols. Our results showed that 4,4'-di-O-methylellagic acid (4,4'-DiOMEA) was the most effective compound in the inhibition of colon cancer cell proliferation. 4,4'-DiOMEA was 13-fold more effective than other compounds of the same family. In addition, 4,4'-DiOMEA was very active against colon cancer cells resistant to the chemotherapeutic agent 5-fluoracil, whereas no effect was observed in nonmalignant colon cells. Moreover, no correlation between antiproliferative and antioxidant activities was found, further supporting that structure differences might result in dissimilar molecular targets involved in their differential effects. Finally, microarray analysis revealed that 4,4'-DiOMEA modulated Wnt signaling, which might be involved in the potential antitumor action of this compound. Our results suggest that structural-activity differences between EA and 4,4'-DiOMEA might constitute the basis for a new strategy in anticancer drug discovery based on these chemical modifications. | - |
dc.description.sponsorship | This research was supported by the Ministerio de Economía y Competitividad del Gobierno de España [Plan Nacional I1D1i AGL2013-48943-C2-2-R and IPT-2011-1248-060000], Comunidad de Madrid [Grant P2013/ABI-2728 ALIBIRD-CM], and European Union Structural Funds. | - |
dc.publisher | American Society for Pharmacology and Experimental Therapeutics | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2013-48943-C2-2-R | - |
dc.relation | S2013/ABI-2728/ALIBIRD-CM | - |
dc.rights | closedAccess | - |
dc.title | The ellagic acid derivative 4,4'-di-O-methylellagic acid efficiently inhibits colon cancer cell growth through a mechanism involving WNT16 | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1124/jpet.114.221796 | - |
dc.date.updated | 2017-05-19T09:57:42Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.contributor.funder | European Commission | - |
dc.contributor.funder | Comunidad de Madrid | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100012818 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
Aparece en las colecciones: | (CIAL) Artículos (CEBAS) Artículos |
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