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Title

Bottlenecks and selective sweeps during domestication have increased deleterious genetic variation in dogs

AuthorsMarsden, Clare D.; Ortega-Del Vecchyo, D.; O’Brien, Dennis P.; Taylor, Jeremy F.; Ramírez, Óscar ; Vilà, Carles ; Marqués-Bonet, Tomàs ; Schnabel, Robert D.; Wayne, Robert K.; Lohmueller, Kirk E.
KeywordsDeleterious mutations
Domestication
Bottleneck
Selective sweep
Issue Date5-Jan-2016
PublisherNational Academy of Sciences (U.S.)
CitationProceedings of the National Academy of Sciences 113(1): 152-157 (2016)
AbstractDogs have an integral role in human society, and recent evidence suggests they have a unique bond that elicits a beneficial hormonal response in both dogs and human handlers. Here, we show this relationship has a dark side. Small population size during domestication and strong artificial selection for breed-defining traits has unintentionally increased the numbers of deleterious genetic variants. Our findings question the overly typological practice of breeding individuals that best fit breed standards, a Victorian legacy. This practice does not allow selection to remove potentially deleterious variation associated with genes responsible for breed-specific traits.
Publisher version (URL)http://doi.org/10.1073/pnas.1512501113
URIhttp://hdl.handle.net/10261/149974
DOI10.1073/pnas.1512501113
ISSN1091-6490
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(IBE) Artículos
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