English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/149974
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Bottlenecks and selective sweeps during domestication have increased deleterious genetic variation in dogs

AuthorsMarsden, Clare D.; Ortega-Del Vecchyo, D.; O’Brien, Dennis P.; Taylor, Jeremy F.; Ramírez, Óscar ; Vilà, Carles ; Marqués-Bonet, Tomàs ; Schnabel, Robert D.; Wayne, Robert K.; Lohmueller, Kirk E.
KeywordsDeleterious mutations
Selective sweep
Issue Date5-Jan-2016
PublisherNational Academy of Sciences (U.S.)
CitationProceedings of the National Academy of Sciences 113(1): 152-157 (2016)
AbstractDogs have an integral role in human society, and recent evidence suggests they have a unique bond that elicits a beneficial hormonal response in both dogs and human handlers. Here, we show this relationship has a dark side. Small population size during domestication and strong artificial selection for breed-defining traits has unintentionally increased the numbers of deleterious genetic variants. Our findings question the overly typological practice of breeding individuals that best fit breed standards, a Victorian legacy. This practice does not allow selection to remove potentially deleterious variation associated with genes responsible for breed-specific traits.
Publisher version (URL)http://doi.org/10.1073/pnas.1512501113
Appears in Collections:(EBD) Artículos
(IBE) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.