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Regioselective Palmitoylation of 9-(2,3-Dihydroxy- propyl)adenine Catalyzed by a Glycopolymer-enzyme Conjugate

AuthorsBrabcová, Jana; Blazek, J.; Krecmerová, Marcela; Vondrášek, Jiří; Palomo, José Miguel ; Zarevúcka, Marie
Issue Date16-May-2016
PublisherMultidisciplinary Digital Publishing Institute
CitationMolecules 21 (5): 648 (2016)
AbstractThe enzymatic regioselective monopalmitoylation of racemic 9-(2,3-dihydroxypropyl)- adenine (DHPA), an approved antiviral agent, has been performed by an immobilized form of <i>Candida antarctica</i> B lipase (CAL-B) using a 4:1 DMF/hexane mixture as the reaction medium. To improve the chemical yield of the desired monopalmitoylation reaction, solid-phase chemical modifications of the lipase were evaluated. The reaction yield was successfully increased obtaining 100% product after a second treatment of the product solution with fresh immobilised chemically glycosylated-CAL-B.
Publisher version (URL)http://doi.org/10.3390/molecules21050648
Identifiersdoi: 10.3390/molecules21050648
Appears in Collections:(ICP) Artículos
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