English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/149129
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Intramolecular Benzoin Reaction Catalyzed by Benzaldehyde Lyase from Pseudomonas Fluorescens Biovar I

AuthorsHernández Sánchez, Karel ; Parella, T.; Petrillo, Giovanna ; Usón, Isabel ; Wandtke, Claudia M.; Joglar Tamargo, Jesús ; Bujons, Jordi; Clapés Saborit, Pere
Keywordsasymmetric catalysis
biocatalysis
C−C coupling
enzymes
macrocycles
Issue Date2-May-2017
PublisherWiley-VCH
CitationAngewandte Chemie - International Edition 56 (19): 5304-5307 (2017)
AbstractIntramolecular benzoin reactions catalyzed by benzaldehyde lyase from Pseudomonas fluorescens biovar I (BAL) are reported. The structure of the substrates envisaged for this reaction consists of two benzaldehyde derivatives linked by an alkyl chain. The structural requirements needed to achieve the intramolecular carbon–carbon bond reaction catalyzed by BAL were established. Thus, a linker consisting of a linear alkyl chain of three carbon atoms connected through ether-type bonds to the 2 and 2′ positions of two benzaldehyde moieties, which could be substituted with either Cl, Br, or OCH3 at either the 3 and 3′ or 5 and 5′ positions, were suitable substrates for BAL. Reactions with 61–84 % yields of the intramolecular product and ee values between 64 and 98 %, were achieved. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
URIhttp://hdl.handle.net/10261/149129
DOI10.1002/anie.201702278
Appears in Collections:(IQAC) Artículos
Files in This Item:
File Description SizeFormat 
Intramolecular Benzoin Reaction Catalyzed by Benzaldehyde.pdf246,5 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.