English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/149077
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Oligonucleotide-Lipid Conjugates Forming G-Quadruplex Structures Are Potent and Pangenotypic Hepatitis C Virus Entry Inhibitors In Vitro and Ex Vivo

AuthorsKoutsoudakis, George; Paris de León, Alexia; Herrera, Carolina; Dorner, Marcus; Pérez-Vilaró, Gemma; Lyonnais, Sébastien; Grijalvo, Santiago ; Eritja Casadellà, Ramón ; Meyerhans, Andreas; Mirambeau, Gilles; Díez, Juana
Keywordsoligonucleotide-cholesterol conjugates
DNA G-quadruplex structures
antiviral treatment
HCV entry inhibitor
HCV cell-to-cell inhibitor
HCV pangenotypic inhibitor
Issue DateMay-2017
PublisherAmerican Society for Microbiology
CitationAntimicrobial Agents and Chemotherapy 61(5) e02354-16 (2017)
AbstractA hepatitis C virus (HCV) epidemic affecting HIV-infected men who have sex with men (MSM) is expanding worldwide. In spite of the improved cure rates obtained with the new direct-acting antiviral drug (DAA) combinations, the high rate of reinfection within this population calls urgently for novel preventive interventions. In this study, we determined in cell culture and ex vivo experiments with human colorectal tissue that lipoquads, G-quadruplex DNA structures fused to cholesterol, are efficient HCV pangenotypic entry and cell-to-cell transmission inhibitors. Thus, lipoquads may be promising candidates for the development of rectally applied gels to prevent HCV transmission.
Publisher version (URL)10.1128/AAC.02354-16
Appears in Collections:(IQAC) Artículos
Files in This Item:
File Description SizeFormat 
koutsodakis2017AAC.pdf1,27 MBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.