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Title

Oligonucleotide-Lipid Conjugates Forming G-Quadruplex Structures Are Potent and Pangenotypic Hepatitis C Virus Entry Inhibitors In Vitro and Ex Vivo

AuthorsKoutsoudakis, George; Paris de León, Alexia; Herrera, Carolina; Dorner, Marcus; Pérez-Vilaró, Gemma; Lyonnais, Sébastien; Grijalvo, Santiago ; Eritja Casadellà, Ramón ; Meyerhans, Andreas; Mirambeau, Gilles; Díez, Juana
Keywordsoligonucleotide-cholesterol conjugates
DNA G-quadruplex structures
antiviral treatment
HCV entry inhibitor
HCV cell-to-cell inhibitor
HCV pangenotypic inhibitor
Issue DateMay-2017
PublisherAmerican Society for Microbiology
CitationAntimicrobial Agents and Chemotherapy 61(5) e02354-16 (2017)
AbstractA hepatitis C virus (HCV) epidemic affecting HIV-infected men who have sex with men (MSM) is expanding worldwide. In spite of the improved cure rates obtained with the new direct-acting antiviral drug (DAA) combinations, the high rate of reinfection within this population calls urgently for novel preventive interventions. In this study, we determined in cell culture and ex vivo experiments with human colorectal tissue that lipoquads, G-quadruplex DNA structures fused to cholesterol, are efficient HCV pangenotypic entry and cell-to-cell transmission inhibitors. Thus, lipoquads may be promising candidates for the development of rectally applied gels to prevent HCV transmission.
Publisher version (URL)10.1128/AAC.02354-16
URIhttp://hdl.handle.net/10261/149077
DOI10.1128/AAC.02354-16
Appears in Collections:(IQAC) Artículos
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