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Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/14892
Title: Antinociceptive, anti-inflammatory and antipyretic effects of lapidin, a bicyclic sesquiterpene
Authors: Valencia, Emir; Feria, Manuel; Díaz, Jesús G.; González, Antonio G.; Bermejo, Jaime
Keywords: Lapidin
Ferula linkii Webb
Bicyclic sesquiterpenes
Antipyretic compounds
Issue Date: Oct-1994
Publisher: Thieme
Citation: Planta Medica 60(5): 395-399 (1994)
Abstract: Lapidin, a bicyclic sesquiterpene from Ferula linkii Webb, has been evaluated for antinociceptive, anti-inflammatory, and antipyretic activities in mice and rats. Lapidin, vehicle, or the appropriate reference analgesic and anti-inflammatory compounds (acetylsalicylic acid [ASA] and indomethacin) were injected i.p. The more conspicuous effects of lapidin were: 1) a significant protective effect (17-62%; 2.5-20 mg/kg) towards writhings and stretchings induced by acetic acid in mice; 2) a significant antinociceptive effect on jumping responses in the hot-plate test (120 seconds at 15 mg/kg vs. 40 and 85 seconds in vehicle and ASA-treated mice, respectively); 3) a significant dose-dependent (5-15 mg/kg) antinociceptive effect against mechanical noxious stimuli; 4) a dose-dependent anti-inflammatory effect in the carrageen-an-induced edema which, at the higher dose (20 mg/kg), was comparable (65% inhibition of paw swelling at 3 hours) to that obtained after indomethacin (10 mg/kg); and 5) a moderate antipyretic effect against yeast-induced hyperthermia. Present results demonstrate that lapidin possesses antinociceptive, anti-inflammatory, and less pronounced antipyretic effects comparable to those of classical non-steroid anti-inflammatory drugs, which make it worthy of further investigations as an antinociceptive and anti-inflammatory drug.
Description: 5 pages.-- PMID: 7997463 [PubMed].-- A preliminary account of some of these results has been presented at the I Simposio Internacional de Química de Productos Naturales y sus Aplicaciones (Universidad Técnica Federico Santa María, Valparaíso, Chile, Sep 24-26, 1992).
Publisher version (URL): http://dx.doi.org/10.1055/s-2006-959517
URI: http://hdl.handle.net/10261/14892
ISSN: 0032-0943
DOI: 10.1055/s-2006-959517
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