Ciencia y Tecnologías Químicas >
Instituto de Productos Naturales y Agrobiología (IPNA) >
(IPNA) Artículos >
Closed Access item Antinociceptive, anti-inflammatory and antipyretic effects of lapidin, a bicyclic sesquiterpene
Díaz, Jesús G.
González, Antonio G.
|Keywords:||Lapidin, Ferula linkii Webb, Apiaceae, Bicyclic sesquiterpenes, Antinociceptive, Anti-inflammatory, Antipyretic compounds|
|Citation:||Planta Medica 60(5): 395-399 (1994)|
|Abstract:||Lapidin, a bicyclic sesquiterpene from Ferula linkii Webb, has been evaluated for antinociceptive, anti-inflammatory, and antipyretic activities in mice and rats. Lapidin, vehicle, or the appropriate reference analgesic and anti-inflammatory compounds (acetylsalicylic acid [ASA] and indomethacin) were injected i.p. The more conspicuous effects of lapidin were: 1) a significant protective effect (17-62%; 2.5-20 mg/kg) towards writhings and stretchings induced by acetic acid in mice; 2) a significant antinociceptive effect on jumping responses in the hot-plate test (120 seconds at 15 mg/kg vs. 40 and 85 seconds in vehicle and ASA-treated mice, respectively); 3) a significant dose-dependent (5-15 mg/kg) antinociceptive effect against mechanical noxious stimuli; 4) a dose-dependent anti-inflammatory effect in the carrageen-an-induced edema which, at the higher dose (20 mg/kg), was comparable (65% inhibition of paw swelling at 3 hours) to that obtained after indomethacin (10 mg/kg); and 5) a moderate antipyretic effect against yeast-induced hyperthermia. Present results demonstrate that lapidin possesses antinociceptive, anti-inflammatory, and less pronounced antipyretic effects comparable to those of classical non-steroid anti-inflammatory drugs, which make it worthy of further investigations as an antinociceptive and anti-inflammatory drug.|
|Description:||5 pages.-- PMID: 7997463 [PubMed].-- A preliminary account of some of these results has been presented at the I Simposio Internacional de Química de Productos Naturales y sus Aplicaciones (Universidad Técnica Federico Santa María, Valparaíso, Chile, Sep 24-26, 1992).|
|Publisher version (URL):||http://dx.doi.org/10.1055/s-2006-959517|
|Appears in Collections:||(IPNA) Artículos|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.