Enhancement of albendazole dissolution properties using solid dispersions with Gelucire 50/13 and PEG 15000

Abstract

The role of two carriers -Gelucire 50/13 and PEG 15000- was evaluated to improve the characteristics of the dissolution of albendazole, an anthelmintic drug with very low solubility and dissolution rate. Solid dispersions were elaborated by using the fusion method. The results from solid-state characterisation techniques (DSC, HSM, FTIR and PXRD) reported immiscibility and absence of interactions in the solid phase.In vitro release studies of binary systems showed a substantial enhancement of dissolution performance when compared with the control, which constitutes an actual alternative to increase the bioavalilability and/or reduce the dosage of the currently marketed formulations.