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Título

Lipid-based nanovesicles for nanomedicine

AutorGrimaldi , Natascia; Andrade, Fernanda; Segovia Ramos, Nathaly V.; Ferrer Tasies, Lidia P. ; Sala Vergés, Santiago ; Veciana, Jaume ; Ventosa, Nora
Palabras claveReverse-phase evaporation
Drug-delivery system
Supercritical carbon-dioxide
Nonionic surfactant vesicles
Large unilamellar vesicles
In-vitro characterization
pH-sensitive liposomes
Targeted delivery
Fecha de publicación7-dic-2016
EditorRoyal Society of Chemistry (Great Britain)
CitaciónChemical Society Reviews 45 (23): 6520-6545 (2016)
ResumenMolecular self-assembly has enabled the fabrication of biologically inspired, advanced nanostructures as lipid-based nanovesicles (L-NVs). The oldest L-NVs, liposomes, have been widely proposed as potential candidates for drug delivery, diagnostic and/or theranostic applications and some liposome-based drug products have already stepped from the lab-bench to the market. This success is attributed to their ability to encapsulate both hydrophobic and/or hydrophilic molecules, efficiently carry and protect them within the body and finally deliver them at the target site. These positive features are also coupled with high biocompatibility. However, liposomes still present some unsolved drawbacks, such as poor colloidal stability, short shelf-life, restricted and expensive conditions of preparation because of the inherent nature of their fundamental constituents (phospholipids). The new tools available in the self-assembly of controlled molecules have significantly advanced the field of L-NV design and synthesis, and nonliposomal L-NVs have been recently developed; this new generation of nanovesicles can represent a paradigm shift in nanomedicine: they may complement liposomes, showing their advantages and overcoming most of their drawbacks. Clearly, being still young, their rocky way to the clinic first and then to the market has just started and it is still long, but they have all the potentialities to reach their objective target. The purpose of this review is to first present the large plethora of L-NVs available, focusing on this new generation of non-liposomal L-NVs and showing their similarities and differences with respect to their ancestors (liposomes). Since the overspread of a nanomaterial to the market is also strongly dependent on the availability of technological-scale preparation methods, we will also extensively review the current approaches exploited for L-NV production. The most cutting-edge approaches based on compressed fluid (CF) technologies will be highlighted here since they show the potential to represent a game-change in the production of L-NVs, favouring their step from the bench to the market. Finally, we will briefly discuss L-NV applications in nanomedicine, looking also for their future perspectives.
Versión del editorhttp://dx.doi.org/10.1039/C6CS00409A
URIhttp://hdl.handle.net/10261/148613
DOI10.1039/C6CS00409A
ISSN0306-0012
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