English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/148554
Share/Impact:
Statistics
logo share SHARE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

Improvement on binding of chondroitin sulfate derivatives to midkine by increasing hydrophobicity

AuthorsPaz, José L. de; Nieto, Pedro M.
Issue Date2016
PublisherRoyal Society of Chemistry (UK)
CitationOrganic and Biomolecular Chemistry 14: 3506- 3509 (2016)
AbstractThe interactions between chondroitin sulfate (CS) and a wide number of proteins modulate important biological processes. Here, the binding properties to midkine and pleiotrophin of sulfated, fully protected intermediates, typically obtained in the chemical synthesis of CS oligosaccharides, were tested for the first time. Using a fluorescence polarization competition experiment, we discovered that these synthetic precursors strongly bound these two closely related cytokines involved in cancer and inflammation. The relative binding affinities of these intermediates were significantly higher than those displayed by the corresponding fully deprotected oligosaccharides, indicating that the presence of hydrophobic protecting groups strongly enhanced the binding of CS-like derivatives to midkine. These compounds offer novel opportunities for the development of potent inhibitors/activators of CS-protein interactions with potential therapeutic applications.
URIhttp://hdl.handle.net/10261/148554
DOI10.1039/c6ob00389c
Identifiersdoi: 10.1039/c6ob00389c
issn: 1477-0520
Appears in Collections:(IIQ) Artículos
Files in This Item:
File Description SizeFormat 
OBC De Paz JL 2016.docx2,72 MBMicrosoft Word XMLView/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.