English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/148413
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Antihypertensive Mechanism of Lactoferrin-Derived Peptides: Angiotensin Receptor Blocking Effect

AuthorsFernández-Musoles, Ricardo ; Castelló-Ruiz, María; Arce, Cristina; Manzanares, Paloma ; Ivorra, M. Dolores; Salom, Juan B.
KeywordsAngiotensin receptor blocker
Angiotensin-converting enzyme inhibition
Antihypertensive mechanism
Bovine lactoferrin hydrolysate
Lactoferrin-derived peptides
Renin−angiotensin system
Issue Date19-Dec-2013
PublisherAmerican Chemical Society
CitationJournal of Agricultural and Food Chemistry 62(1): 173-181 (2014)
AbstractLooking for antihypertensive mechanisms beyond ACE inhibition, we assessed whether lactoferrin (LF)-derived peptides can act as receptor blockers to inhibit vasoconstriction induced by angiotensin II or endothelin-1. The lactoferricin B (LfcinB)-derived peptide LfcinB20–25 (RRWQWR), the low molecular weight LF hydrolysate (LFH < 3 kDa), and two peptides identified in LFH < 3 kDa (LIWKL and RPYL) were tested in ex vivo assays of vasoactive responses. The peptide RPYL was tested in radioligand receptor binding assays. Both LFH < 3 kDa and individual peptides inhibited angiotensin II-induced vasoconstriction. RPYL showed the highest ex vivo inhibitory effect and also inhibited binding of [125I]-(Sar1,Ile8)-angiotensin II to AT1 receptors. By contrast, neither LFH < 3 kDa nor RPYL inhibited endothelin-1 and depolarization-induced vasoconstrictions. In conclusion, LF-derived peptides selectively inhibit angiotensin II-induced vasoconstriction by blocking angiotensin AT1 receptors. Therefore, inhibition of angiotensin II-induced vasocontriction is suggested as a mechanism contributing along with ACE inhibition to the antihypertensive effect of some LF-derived peptides.
DescriptionTexto del artículo, no incluye figuras ni tablas.
Publisher version (URL)http://dx.doi.org/10.1021/jf404616f
URIhttp://hdl.handle.net/10261/148413
DOI10.1021/jf404616f
ISSN0021-8561
Appears in Collections:(IATA) Artículos
Files in This Item:
File Description SizeFormat 
Fernandez-Musoles-JAFC2014.pdfArtículo principal, sin figuras ni tablas238,51 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.