English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/148283
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Carbohydrate-Binding Non-Peptidic Pradimicins for the Treatment of Acute Sleeping Sickness in Murine Models

AuthorsCastillo Acosta, Víctor M.; Ruiz-Pérez, Luis Miguel; Etxebarria, Juan; Reichardt, Niels Christian; Navarro, M.; Igarashi, Yasuhiro; Liekens, Sandra; Balzarini, Jan; González-Pacanowska, D.
KeywordsFRONTAL AFFINITY-CHROMATOGRAPHY
TRYPANOSOMA-BRUCEI
AFRICAN TRYPANOSOMES
MESSENGER-RNAS
URTICA-DIOICA
HUMAN-IMMUNODEFICIENCY-VIRUS
Issue Date23-Sep-2016
PublisherPublic Library of Science
CitationPLoS Pathogens
AbstractCurrent treatments available for African sleeping sickness or human African trypanosomiasis (HAT) are limited, with poor efficacy and unacceptable safety profiles. Here, we report a new approach to address treatment of this disease based on the use of compounds that bind to parasite surface glycans leading to rapid killing of trypanosomes. Pradimicin and its derivatives are non-peptidic carbohydrate-binding agents that adhere to the carbohydrate moiety of the parasite surface glycoproteins inducing parasite lysis in vitro. Notably, pradimicin S has good pharmaceutical properties and enables cure of an acute form of the disease in mice. By inducing resistance in vitro we have established that the composition of the sugars attached to the variant surface glycoproteins are critical to the mode of action of pradimicins and play an important role in infectivity. The compounds identified represent a novel approach to develop drugs to treat HAT.
Publisher version (URL)http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005851
URIhttp://hdl.handle.net/10261/148283
DOIhttp://dx.doi.org/10.1371/journal.ppat.1005851
ISSN1553-7366
E-ISSN1553-7374
Appears in Collections:(IPBLN) Artículos
Files in This Item:
File Description SizeFormat 
Carbohydrate_Binding_Plos_Pathogens_2016.pdf945,58 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.